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- 01GQHH38CGMG3RW3QEMW8Q2B41 classification A1.
- 01GQHH38CGMG3RW3QEMW8Q2B41 date "2023".
- 01GQHH38CGMG3RW3QEMW8Q2B41 language "eng".
- 01GQHH38CGMG3RW3QEMW8Q2B41 type journalArticle.
- 01GQHH38CGMG3RW3QEMW8Q2B41 hasPart 01GQHJ0K1PKTQD7Z2XEQRMEQWT.pdf.
- 01GQHH38CGMG3RW3QEMW8Q2B41 hasPart 01GQHJ12M0MX1MF3DP8DFAN8H0.xlsx.
- 01GQHH38CGMG3RW3QEMW8Q2B41 hasPart 01GQHJ1CNPWAX7W0HN7PJH9AZR.xlsx.
- 01GQHH38CGMG3RW3QEMW8Q2B41 hasPart 01GQHJ1QNTHW8QV5STZHMVWM6H.xlsx.
- 01GQHH38CGMG3RW3QEMW8Q2B41 hasPart 01GQHJ22KVSR493RCC039ZVAWM.xlsx.
- 01GQHH38CGMG3RW3QEMW8Q2B41 hasPart 01GXWVJ99WHCGK7Y4XHTYZAEAN.pdf.
- 01GQHH38CGMG3RW3QEMW8Q2B41 hasPart urn:uuid:b5d51132-7323-42f1-bdbf-69dc632a71e6.
- 01GQHH38CGMG3RW3QEMW8Q2B41 subject "Biology and Life Sciences".
- 01GQHH38CGMG3RW3QEMW8Q2B41 doi "10.1093/nar/gkac1244".
- 01GQHH38CGMG3RW3QEMW8Q2B41 issn "0305-1048".
- 01GQHH38CGMG3RW3QEMW8Q2B41 issn "1362-4962".
- 01GQHH38CGMG3RW3QEMW8Q2B41 issue "6".
- 01GQHH38CGMG3RW3QEMW8Q2B41 volume "51".
- 01GQHH38CGMG3RW3QEMW8Q2B41 abstract "At meiosis, programmed meiotic DNA double-strand breaks are repaired via homologous recombination, resulting in crossovers (COs). From a large excess of DNA double-strand breaks that are formed, only a small proportion gets converted into COs because of active mechanisms that restrict CO formation. The Fanconi anemia (FA) complex proteins AtFANCM, MHF1 and MHF2 were previously identified in a genetic screen as anti-CO factors that function during meiosis in Arabidopsis thaliana. Here, pursuing the same screen, we identify FANCC as a new anti-CO gene. FANCC was previously only identified in mammals because of low primary sequence conservation. We show that FANCC, and its physical interaction with FANCE-FANCF, is conserved from vertebrates to plants. Further, we show that FANCC, together with its subcomplex partners FANCE and FANCF, regulates meiotic recombination. Mutations of any of these three genes partially rescues CO-defective mutants, which is particularly marked in female meiosis. Functional loss of FANCC, FANCE, or FANCF results in synthetic meiotic catastrophe with the pro-CO factor MUS81. This work reveals that FANCC is conserved outside mammals and has an anti-CO role during meiosis together with FANCE and FANCF. Plain language summary The Fanconi Anemia (FA) pathway is the subject of intense interest owing to the role of FA as a tumor suppressor. Three FA complex proteins, FANCM, MHF1 and MHF2, were identified as factors that suppress crossover during meiosis in the model plant Arabidopsis thaliana. Here, the authors extended these findings and identified a novel anti-crossover factor and showed that it encodes the plant FANCC homolog, which was previously thought to be vertebrate-specific. They further showed that FANCC regulates meiotic crossover together with two other FA proteins, FANCE and FANCF. This suggests that the FANCC–E–F subcomplex was already regulating DNA repair in the common ancestor of all living eukaryotes.".
- 01GQHH38CGMG3RW3QEMW8Q2B41 author F49A569E-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GQHH38CGMG3RW3QEMW8Q2B41 author F6B65B3A-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GQHH38CGMG3RW3QEMW8Q2B41 author urn:uuid:1f86aa69-94ed-4b4a-bb7d-0409bf6d77cb.
- 01GQHH38CGMG3RW3QEMW8Q2B41 author urn:uuid:2960e3e2-aa72-4585-b016-21ef0f7b6aa9.
- 01GQHH38CGMG3RW3QEMW8Q2B41 author urn:uuid:2abf9dcd-3860-427e-8ec9-a0a733a9a4db.
- 01GQHH38CGMG3RW3QEMW8Q2B41 author urn:uuid:5bb42d75-de30-449a-944a-b86cb8bd6b67.
- 01GQHH38CGMG3RW3QEMW8Q2B41 author urn:uuid:69add04e-8e5d-4cc3-b97f-c314d5b498a7.
- 01GQHH38CGMG3RW3QEMW8Q2B41 author urn:uuid:7ac55faa-a2ed-46ae-8d86-b876025c4f2f.
- 01GQHH38CGMG3RW3QEMW8Q2B41 author urn:uuid:81c9eb55-b70d-4925-96d5-9a96eec46b9f.
- 01GQHH38CGMG3RW3QEMW8Q2B41 author urn:uuid:c81105a2-0686-4f49-afb6-42094f4d25d2.
- 01GQHH38CGMG3RW3QEMW8Q2B41 dateCreated "2023-01-24T09:17:41Z".
- 01GQHH38CGMG3RW3QEMW8Q2B41 dateModified "2024-12-12T20:20:39Z".
- 01GQHH38CGMG3RW3QEMW8Q2B41 name "The FANCC–FANCE–FANCF complex is evolutionarily conserved and regulates meiotic recombination".
- 01GQHH38CGMG3RW3QEMW8Q2B41 pagination urn:uuid:95e29bad-1666-455e-8ae4-e8d8cf652326.
- 01GQHH38CGMG3RW3QEMW8Q2B41 sameAs LU-01GQHH38CGMG3RW3QEMW8Q2B41.
- 01GQHH38CGMG3RW3QEMW8Q2B41 sourceOrganization urn:uuid:07417648-c3d1-410e-bd2c-6d642522f9f9.
- 01GQHH38CGMG3RW3QEMW8Q2B41 sourceOrganization urn:uuid:090758b7-82f5-429d-a9d2-74645140decc.
- 01GQHH38CGMG3RW3QEMW8Q2B41 type A1.