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- 01GQSZWS2CAPR7ZEP471RK4S84 classification A2.
- 01GQSZWS2CAPR7ZEP471RK4S84 date "2022".
- 01GQSZWS2CAPR7ZEP471RK4S84 language "eng".
- 01GQSZWS2CAPR7ZEP471RK4S84 type journalArticle.
- 01GQSZWS2CAPR7ZEP471RK4S84 hasPart 01GQT17WDZ4ZEGGQCFW6H1XNYK.pdf.
- 01GQSZWS2CAPR7ZEP471RK4S84 subject "Biology and Life Sciences".
- 01GQSZWS2CAPR7ZEP471RK4S84 doi "10.1016/j.crbiot.2022.08.003".
- 01GQSZWS2CAPR7ZEP471RK4S84 issn "2590-2628".
- 01GQSZWS2CAPR7ZEP471RK4S84 volume "4".
- 01GQSZWS2CAPR7ZEP471RK4S84 abstract "UDP-galactose 4-epimerase (Gal4E, EC 5.1.3.2) catalyses the interconversion of UDP-galactose and UDPglucose by inverting the configuration of the 4'-hydroxyl group of the sugar moiety. This enzyme is one of the mechanistically best-characterized members of the Short-chain Dehydrogenase/Reductase (SDR) superfamily. Although Gal4E was widely studied throughout all domains of life, ranging from eukaryotes to archaea, its biochemical characterization was often limited to UDP-hexoses, neglecting the possibility that Gal4E might be promiscuous towards other NDP-sugars and derivatives thereof. In this study, we identified a novel Gal4E subgroup displaying an unprecedented specificity on guanosine diphosphate (GDP) sugars. As a proof of concept, a detailed biochemical investigation was performed on Gal4E from Pyrococcus horikoshii (phGal4E_1), which revealed that it has, in fact, a clear preference for GDP-sugars. In addition, we confirmed that it accepts a variety of other sugar moieties, including L-sugars like L-galactose and L-fucose.".
- 01GQSZWS2CAPR7ZEP471RK4S84 author 1EFD937C-7705-11E7-9747-CC8DAD28A064.
- 01GQSZWS2CAPR7ZEP471RK4S84 author F61853C2-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GQSZWS2CAPR7ZEP471RK4S84 author FA01B258-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GQSZWS2CAPR7ZEP471RK4S84 author fa82d5a9-6259-11ea-8326-9bb73d7877be.
- 01GQSZWS2CAPR7ZEP471RK4S84 dateCreated "2023-01-27T16:10:13Z".
- 01GQSZWS2CAPR7ZEP471RK4S84 dateModified "2024-10-29T08:51:38Z".
- 01GQSZWS2CAPR7ZEP471RK4S84 name "Exploration of archaeal nucleotide sugar epimerases unveils a new and highly promiscuous GDP-Gal4E subgroup".
- 01GQSZWS2CAPR7ZEP471RK4S84 pagination urn:uuid:e7b213cd-02e1-406f-a77e-747662946b91.
- 01GQSZWS2CAPR7ZEP471RK4S84 sameAs LU-01GQSZWS2CAPR7ZEP471RK4S84.
- 01GQSZWS2CAPR7ZEP471RK4S84 sourceOrganization urn:uuid:64f45dce-0727-433e-a003-50c3a8f8b2c9.
- 01GQSZWS2CAPR7ZEP471RK4S84 type A2.