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- 01GRBNXX5VPKGPNSERFSXTEAJ4 classification A2.
- 01GRBNXX5VPKGPNSERFSXTEAJ4 date "2018".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 language "eng".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 type journalArticle.
- 01GRBNXX5VPKGPNSERFSXTEAJ4 hasPart 01GRBQJG0WRC9VPPTTAW4VYY3W.pdf.
- 01GRBNXX5VPKGPNSERFSXTEAJ4 subject "Medicine and Health Sciences".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 doi "10.1093/ehjcr/yty130".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 issn "2514-2119".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 issue "4".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 volume "2".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 abstract "Background Statins are one of the most frequently used drug groups among patients with cardiovascular disease. Muscle pain is very frequent among patients using statins. It is important to distinguish patients with benign muscle pain without significant biochemical correlates from patients with serious myopathies. Case summary We present the case of a 68-year-old woman taking atorvastatin in the past 8 months after a coronary bypass grafting, presenting with proximal muscle weakness and pain. Biochemical analysis showed a markedly elevated creatine kinase (CK) (24,159 U/L). Despite discontinuation of the statin and therapy for rhabdomyolysis (IV fluid, mannitol, and sodium bicarbonate), CK levels did not drop as much as expected. Muscle biopsy showed mild inflammatory changes and few necrotic muscle fibres, suggestive for an immune-mediated necrotizing myopathy (IMNM). Serology showed a high anti-HMG-CoA reductase antibody (anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody) titre, diagnostic for an IMNM induced by statins. The patient was treated with corticosteroids and methotrexate. Creatine kinase levels, muscle weakness, and pain gradually improved over the following months. Discussion IMNM induced by statins is a relatively new entity. It is important to be recognized because it is not a self-limiting adverse effect such as the frequent benign muscle pains caused by statins. Beside discontinuation of the causative statin, aggressive immunosuppressive therapy is mandatory in IMNM. Therefore, it is important to test for anti-HMGCR antibodies and if necessary perform a muscle biopsy in patients taking statins, presenting with muscle weakness, and CK elevations not improving after discontinuation of the statin.".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 author 10E26D46-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GRBNXX5VPKGPNSERFSXTEAJ4 author urn:uuid:4db1070e-23e2-4401-bee1-44f0d2a2e0ab.
- 01GRBNXX5VPKGPNSERFSXTEAJ4 author urn:uuid:63398184-4458-43b7-b5a2-d47055c03f01.
- 01GRBNXX5VPKGPNSERFSXTEAJ4 author urn:uuid:d4b498e6-868d-4ec0-b8ea-490de7912b40.
- 01GRBNXX5VPKGPNSERFSXTEAJ4 dateCreated "2023-02-03T13:02:24Z".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 dateModified "2024-07-09T07:43:16Z".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 name "Statin-induced myopathy : a case report".
- 01GRBNXX5VPKGPNSERFSXTEAJ4 pagination urn:uuid:2fa0f8a1-ec59-490f-8ea7-aab3c7dabdae.
- 01GRBNXX5VPKGPNSERFSXTEAJ4 sameAs LU-01GRBNXX5VPKGPNSERFSXTEAJ4.
- 01GRBNXX5VPKGPNSERFSXTEAJ4 sourceOrganization urn:uuid:415ac520-a8e2-4606-a8e0-35636f36e8ff.
- 01GRBNXX5VPKGPNSERFSXTEAJ4 type A2.