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- 01GRPTB1B7TXFKMJNGQ0EYCE5T classification A1.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T date "2023".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T language "eng".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T type journalArticle.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T hasPart 01HFYE55H3NDVJJ9DEF7TW4F1M.pdf.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T hasPart urn:uuid:6101e130-5290-4322-bcfd-54caf705714c.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T subject "Biology and Life Sciences".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T doi "10.1007/s10719-022-10094-4".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T issn "0282-0080".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T issn "1573-4986".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T issue "1".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T volume "40".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T abstract "The S protein forming the homotrimeric spikes of pathogenic beta-coronaviruses, such as MERS-CoV, SARS-CoV and SARS-CoV-2, is a highly glycosylated protein containing mainly N-glycans of the complex and high-mannose type, as well as O-glycans. Similarly, the host cell receptors DPP4 for MERS-CoV and ACE2 for SARS-CoV and SARS-CoV-2, also represent N- and O-glycosylated proteins. All these glycoproteins share common glycosylation patterns, suggesting that plant lectins with different carbohydrate-binding specificities could be used as carbohydrate-binding agents for the spikes and their receptors, to combat COVID19 pandemics. The binding of plant lectins to the spikes and their receptors could mask the non-glycosylated receptor binding domain of the virus and the corresponding region of the receptor, thus preventing a proper interaction of the spike proteins with their receptors. In this review, we analyze (1) the ability of plant lectins to interact with the N- and O-glycans present on the spike proteins and their receptors, (2) the in vitro and in vivo anti-COVID19 activity already reported for plant lectins and, (3) the possible ways for delivery of lectins to block the spikes and/or their receptors.".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T author F67A8F2E-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T author urn:uuid:1566fbf5-7b04-497c-b1e4-58c3ccb46536.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T author urn:uuid:23bc2ed0-d141-47c1-b57e-18605523ae16.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T author urn:uuid:49e77d96-dbe2-40ea-b80c-a92c83061d5e.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T author urn:uuid:6d41f6d0-5694-444d-9ae1-790bf0ed63d0.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T author urn:uuid:7ef50832-3598-48e5-926d-2890e3ffa6a7.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T author urn:uuid:ad3f2ca2-f4cd-4542-a1d9-d193674f4086.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T dateCreated "2023-02-07T20:51:07Z".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T dateModified "2024-12-12T18:03:00Z".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T name "Plant lectins as versatile tools to fight coronavirus outbreaks".
- 01GRPTB1B7TXFKMJNGQ0EYCE5T pagination urn:uuid:305c7ebc-96d7-4763-bc83-51d5c336d7b4.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T sameAs LU-01GRPTB1B7TXFKMJNGQ0EYCE5T.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T sourceOrganization urn:uuid:18c880c4-67f8-470d-8634-3636b2402626.
- 01GRPTB1B7TXFKMJNGQ0EYCE5T type A1.