Matches in Ghent University Academic Bibliography for { <https://biblio.ugent.be/publication/01GRQ4PY6C7V19MCPHJN6ZZN5J> ?p ?o. }
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- 01GRQ4PY6C7V19MCPHJN6ZZN5J classification A1.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J date "2023".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J language "eng".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J type journalArticle.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J hasPart 01GRQ4T28ENG157DZET1R7YFDP.pdf.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J subject "Biology and Life Sciences".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J subject "Medicine and Health Sciences".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J doi "10.1073/pnas.2208425120".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J issn "0027-8424".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J issn "1091-6490".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J issue "4".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J volume "120".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J abstract " Recurrent spillovers of & alpha;- and (3-coronaviruses (CoV) such as severe acute respiratory syndrome (SARS)-CoV, Middle East respiratory syndrome-CoV, SARS-CoV-2, and possibly human CoV have caused serious morbidity and mortality worldwide. In this study, six receptor-binding domains (RBDs) derived from & alpha;- and (3-CoV that are con-sidered to have originated from animals and cross-infected humans were linked to a heterotrimeric scaffold, proliferating cell nuclear antigen (PCNA) subunits, PCNA1, PCNA2, and PCNA3. They assemble to create a stable mosaic multivalent nanoparticle, 6RBD-np, displaying a ring-shaped disk with six protruding antigens, like jewels in a crown. Prime-boost immunizations with 6RBD-np in mice induced significantly high Ab titers against RBD antigens derived from & alpha;- and (3-CoV and increased interferon (IFN-& gamma;) production, with full protection against the SARS-CoV-2 wild type and Delta challenges. The mosaic 6RBD-np has the potential to induce intergenus cross-reactivity and to be developed as a pan-CoV vaccine against future CoV spillovers.".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author CB1B1224-07E0-11E5-AD53-88F8B4D1D7B1.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author CB23C78E-07E0-11E5-AD53-88F8B4D1D7B1.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:02b2369f-743b-4148-bb6f-d46179038ddb.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:0ea5213f-e269-4b91-afbb-8a925e5ef983.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:1f98b018-900c-4fa5-8fcd-7de0d102bd14.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:28df3ef7-5ac2-4b56-9d0c-8a001b4172b7.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:49b7664f-cd5f-495c-96c9-62dcd6800c64.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:5c373ee9-71bf-4db9-8e25-6bb74db6d2ae.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:60b06411-5510-48c4-a2c0-aa8d919b4f81.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:7d6bbcc6-3735-48e2-b011-4b5b0270194e.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:88ab2e05-3256-404f-a79d-d733efbdddf2.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:8d1763be-b4b5-4808-b131-f2f95dc3d8d7.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:a932dcf0-97c0-4a57-8633-1f98f077b062.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:b31724b8-ac82-4bd7-aef2-e22bd35e884e.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:b3e15a7f-2d59-499f-b0df-87c56e6e97d5.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:c70c462f-c241-4c48-a3a6-3739e717faf2.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:d0147fa6-2c58-4a4b-bb80-52f5330af9ae.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:d6e0d084-61bb-41b5-ac13-765eb6ce004f.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:e0888349-2b0e-4498-9755-2aaea46a49d0.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J author urn:uuid:f111f40c-8e14-49e2-9fcd-45b31d9f3321.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J dateCreated "2023-02-07T23:52:23Z".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J dateModified "2024-12-12T17:55:35Z".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J name "Mosaic RBD nanoparticles induce intergenus cross-reactive antibodies and protect against SARS-CoV-2 challenge".
- 01GRQ4PY6C7V19MCPHJN6ZZN5J pagination urn:uuid:fb9f742f-8e4f-4847-9370-a30b95423fa8.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J sameAs LU-01GRQ4PY6C7V19MCPHJN6ZZN5J.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J sourceOrganization urn:uuid:b8a0f57b-6e58-42ad-bb42-e530e54c4423.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J sourceOrganization urn:uuid:d2652003-9e44-4f6f-977c-0cff0f56c385.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J sourceOrganization urn:uuid:f43b5834-c9c7-4c73-ac05-475f403f3498.
- 01GRQ4PY6C7V19MCPHJN6ZZN5J type A1.