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- 01GSWC0QDW6MWGAFAP48WN5JMT classification C3.
- 01GSWC0QDW6MWGAFAP48WN5JMT date "2023".
- 01GSWC0QDW6MWGAFAP48WN5JMT language "eng".
- 01GSWC0QDW6MWGAFAP48WN5JMT type conference.
- 01GSWC0QDW6MWGAFAP48WN5JMT hasPart 01HQNA8AERRVZSDX47B3MC6XW6.pdf.
- 01GSWC0QDW6MWGAFAP48WN5JMT subject "Technology and Engineering".
- 01GSWC0QDW6MWGAFAP48WN5JMT presentedAt urn:uuid:06f03e46-1cac-4122-8248-87555dc3c92f.
- 01GSWC0QDW6MWGAFAP48WN5JMT abstract "Background At present, it is estimated that over 10% of individuals with clinically-normal audiograms have significant difficulty understanding speech-in-noise (SPiN). Cochlear synaptopathy (CS) – the loss of synapses connecting the cochlea to the auditory nerve (AN), caused by aging or noise exposure – is thought to be an important factor contributing to this problem. Most recent studies addressed CS through its impact on temporal envelope coding, thus missing a component of sounds that is pivotal to SPiN coding, namely their temporal fine structure (TFS). In the present work, we investigated whether complex tones resembling speech vowels could be used to design novel, complementary tools to assess CS through its impact on TFS-coding fidelity. Methods To test this idea, we designed a battery of psychoacoustical detection thresholds and electrophysiological frequency-following responses (FFRs) measurements based on spectrally-complex signals carrying well-defined TFS cues. All measurements were conducted in younger normal-hearing individuals (yNH group, n=18) as well as older individuals with normal hearing (oNH, n=16) or mild-to-moderate hearing loss (oHI, n=14). SPiN scores were also measured: SRTs were obtained with Matrix tests using steady-state, speech-shaped noise presented under several frequency-filtering conditions. Results We will present and discuss all the results obtained from this large data-set. One important result was that the strength of FFRs was strongly reduced in older compared to younger listeners, and negatively correlated to age. In contrast, we found no differences in FFR strength between older listeners with or without sensorineural hearing-loss. These data suggest that cochlear damage per se does not impact the neural coding of TFS cues, but that CS is an important factor underlying the impact of age on TFS-coding capacities. However, we observed no relationships between these neural measurements and SRTs, nor between psychoacoustical detection thresholds of spectral envelope shapes and SRTs in either group, even when speech and noise material were filtered in the low-frequencies so as to maximally engage the use of TFS cues. Conclusions Taken together, these results suggest that FFRs to spectrally-shaped complex signals could provide a novel perspective to monitor CS through its impact on TFS-coding. Yet, these joint psychophysical and electrophysiological results call for further work to design a psychoacoustical test that would provide a robust behavioral proxy of TFS-coding fidelity for such spectrally-shaped sounds. Overall, this project paves the way toward novel non-invasive biological markers of CS based on the neural encoding of spectral cues of sounds. Work supported by Fondation pour l’Audition (FPA 2020-005F2) and European Research Council (ERC-StG-678120, RobSpear).".
- 01GSWC0QDW6MWGAFAP48WN5JMT author 147E0362-7BBC-11E7-9FC6-20D1AD28A064.
- 01GSWC0QDW6MWGAFAP48WN5JMT author DFCD75C4-8046-11E6-BF13-77C3B4D1D7B1.
- 01GSWC0QDW6MWGAFAP48WN5JMT author F4A8B1EE-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GSWC0QDW6MWGAFAP48WN5JMT author f20d318d-0be9-11ea-8e60-9f4419ac13c0.
- 01GSWC0QDW6MWGAFAP48WN5JMT dateCreated "2023-02-22T10:51:58Z".
- 01GSWC0QDW6MWGAFAP48WN5JMT dateModified "2024-10-29T18:34:19Z".
- 01GSWC0QDW6MWGAFAP48WN5JMT name "Designing novel psychophysical and electrophysiological markers of cochlear synaptopathy based on temporal fine structure coding fidelity".
- 01GSWC0QDW6MWGAFAP48WN5JMT sameAs LU-01GSWC0QDW6MWGAFAP48WN5JMT.
- 01GSWC0QDW6MWGAFAP48WN5JMT sourceOrganization urn:uuid:0b4540df-a749-4128-9f7a-5e7a36fdd6a6.
- 01GSWC0QDW6MWGAFAP48WN5JMT sourceOrganization urn:uuid:17f9f1da-634f-4ef6-a401-5e9a2a7ad0d9.
- 01GSWC0QDW6MWGAFAP48WN5JMT sourceOrganization urn:uuid:ca64af23-0f85-477c-a744-85992409e1a1.
- 01GSWC0QDW6MWGAFAP48WN5JMT type C3.