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- 01GSWWM6ASWDAWZVBVKFCNSSHN classification A1.
- 01GSWWM6ASWDAWZVBVKFCNSSHN date "2023".
- 01GSWWM6ASWDAWZVBVKFCNSSHN language "eng".
- 01GSWWM6ASWDAWZVBVKFCNSSHN type journalArticle.
- 01GSWWM6ASWDAWZVBVKFCNSSHN hasPart 01GSWX30GQSWF2HKND9C9K9ZXR.pdf.
- 01GSWWM6ASWDAWZVBVKFCNSSHN hasPart 01GWVXJ6AFR3WS7ZPYE1JMBX5W.pdf.
- 01GSWWM6ASWDAWZVBVKFCNSSHN subject "Biology and Life Sciences".
- 01GSWWM6ASWDAWZVBVKFCNSSHN doi "10.1016/j.biotechadv.2023.108121".
- 01GSWWM6ASWDAWZVBVKFCNSSHN issn "0734-9750".
- 01GSWWM6ASWDAWZVBVKFCNSSHN issn "1873-1899".
- 01GSWWM6ASWDAWZVBVKFCNSSHN volume "64".
- 01GSWWM6ASWDAWZVBVKFCNSSHN abstract "Recombinant proteins (RP) are widely used as biopharmaceuticals, industrial enzymes, or sustainable food source. Yeasts, with their ability to produce complex proteins through a broad variety of cheap carbon sources, have emerged as promising eukaryotic production hosts. As such, the prevalence of yeasts as favourable pro-duction organisms in commercial RP production is expected to increase. Yet, with the selection of a robust production host on the one hand, successful scale-up is dependent on a thorough understanding of the chal-lenging environment and limitations of large-scale bioreactors on the other hand. In the present work, several prominent yeast species, including Saccharomyces cerevisiae, Pichia pastoris, Yarrowia lipolytica, Kluyveromyces lactis and Kluyveromyces marxianus are reviewed for their current state and performance in commercial RP production. Thereafter, the impact of principal process control parameters, including dissolved oxygen, pH, substrate concentration, and temperature, on large-scale RP production are discussed. Finally, technical chal-lenges of process scale-up are identified. To that end, process intensification strategies to enhance industrial feasibility are summarized, specifically highlighting fermentation strategies to ensure sufficient cooling capacity, overcome oxygen limitation, and increase protein quality and productivity. As such, this review aims to contribute to the pursuit of sustainable yeast-based RP production.".
- 01GSWWM6ASWDAWZVBVKFCNSSHN author 24E451EC-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GSWWM6ASWDAWZVBVKFCNSSHN author 3B634392-1D89-11E3-818F-FB6410BDE39D.
- 01GSWWM6ASWDAWZVBVKFCNSSHN author F32CB1B2-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GSWWM6ASWDAWZVBVKFCNSSHN author urn:uuid:0fc7a4f1-e129-435e-b8df-a183b29c147d.
- 01GSWWM6ASWDAWZVBVKFCNSSHN author urn:uuid:5ad26dd7-ea47-4cd4-bafc-105cbb3a1d31.
- 01GSWWM6ASWDAWZVBVKFCNSSHN dateCreated "2023-02-22T15:42:13Z".
- 01GSWWM6ASWDAWZVBVKFCNSSHN dateModified "2024-12-12T17:52:06Z".
- 01GSWWM6ASWDAWZVBVKFCNSSHN name "Challenges and progress towards industrial recombinant protein production in yeasts : a review".
- 01GSWWM6ASWDAWZVBVKFCNSSHN pagination urn:uuid:af809e5a-5dfe-4cbf-87f1-75ac2102b7a8.
- 01GSWWM6ASWDAWZVBVKFCNSSHN sameAs LU-01GSWWM6ASWDAWZVBVKFCNSSHN.
- 01GSWWM6ASWDAWZVBVKFCNSSHN sourceOrganization urn:uuid:9ce4657b-3119-4024-b7e8-b989c1112796.
- 01GSWWM6ASWDAWZVBVKFCNSSHN type A1.