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- 01H3248KYZ64WQ007HHC2Y96EX classification A1.
- 01H3248KYZ64WQ007HHC2Y96EX date "2022".
- 01H3248KYZ64WQ007HHC2Y96EX language "eng".
- 01H3248KYZ64WQ007HHC2Y96EX type journalArticle.
- 01H3248KYZ64WQ007HHC2Y96EX hasPart 01H324A6JWSD3ET7KKB58FYJRF.pdf.
- 01H3248KYZ64WQ007HHC2Y96EX subject "Medicine and Health Sciences".
- 01H3248KYZ64WQ007HHC2Y96EX subject "Physics and Astronomy".
- 01H3248KYZ64WQ007HHC2Y96EX doi "10.1371/journal.pone.0271351".
- 01H3248KYZ64WQ007HHC2Y96EX issn "1932-6203".
- 01H3248KYZ64WQ007HHC2Y96EX issue "7".
- 01H3248KYZ64WQ007HHC2Y96EX volume "17".
- 01H3248KYZ64WQ007HHC2Y96EX abstract "Electrical waves that rotate in the heart organize dangerous cardiac arrhythmias. Finding the region around which such rotation occurs is one of the most important practical questions for arrhythmia management. For many years, the main method for finding such regions was so-called phase mapping, in which a continuous phase was assigned to points in the heart based on their excitation status and defining the rotation region as a point of phase singularity. Recent analysis, however, showed that in many rotation regimes there exist phase discontinuities and the region of rotation must be defined not as a point of phase singularity, but as a phase defect line. In this paper, we use this novel methodology and perform a comparative study of three different phase definitions applied to in silico data and to experimental data obtained from optical voltage mapping experiments on monolayers of human atrial myocytes. We introduce new phase defect detection algorithms and compare them with those that appeared in literature already. We find that the phase definition is more important than the algorithm to identify sudden spatial phase variations. Sharp phase defect lines can be obtained from a phase derived from local activation times observed during one cycle of arrhythmia. Alternatively, similar quality can be obtained from a reparameterization of the classical phase obtained from observation of a single timeframe of transmembrane potential. We found that the phase defect line length was (35.9 +/- 6.2)mm in the Fenton-Karma model and (4.01 +/- 0.55)mm in cardiac human atrial myocyte monolayers. As local activation times are obtained during standard clinical cardiac mapping, the methods are also suitable to be applied to clinical datasets. All studied methods are publicly available and can be downloaded from an institutional web-server.".
- 01H3248KYZ64WQ007HHC2Y96EX author 317C704C-F0EE-11E1-A9DE-61C894A0A6B4.
- 01H3248KYZ64WQ007HHC2Y96EX author urn:uuid:1206c1ca-2835-46c7-b788-3ab3f2677812.
- 01H3248KYZ64WQ007HHC2Y96EX author urn:uuid:a99d1c1f-caf4-4fcd-aa06-4a76bd7ab0f3.
- 01H3248KYZ64WQ007HHC2Y96EX author urn:uuid:c4805d43-b0b6-4926-9801-711fa75748e3.
- 01H3248KYZ64WQ007HHC2Y96EX author urn:uuid:e5f1b892-d7bc-4f04-b61e-e61c91f71907.
- 01H3248KYZ64WQ007HHC2Y96EX dateCreated "2023-06-16T12:53:11Z".
- 01H3248KYZ64WQ007HHC2Y96EX dateModified "2024-10-29T16:23:02Z".
- 01H3248KYZ64WQ007HHC2Y96EX editor urn:uuid:ce5f6270-dfc2-426f-ab29-612583572234.
- 01H3248KYZ64WQ007HHC2Y96EX name "Numerical methods for the detection of phase defect structures in excitable media".
- 01H3248KYZ64WQ007HHC2Y96EX pagination urn:uuid:36dc05dc-8206-4e7f-b89e-b46e73a95c6d.
- 01H3248KYZ64WQ007HHC2Y96EX publisher urn:uuid:2e60dde7-1231-43e0-851a-f66c6f243321.
- 01H3248KYZ64WQ007HHC2Y96EX sameAs LU-01H3248KYZ64WQ007HHC2Y96EX.
- 01H3248KYZ64WQ007HHC2Y96EX sourceOrganization urn:uuid:e4d9e452-1161-48ff-86c2-b234603bc4c6.
- 01H3248KYZ64WQ007HHC2Y96EX type A1.