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- 01H3SAMNWW2WDERPWN837DQ43R classification C3.
- 01H3SAMNWW2WDERPWN837DQ43R date "2023".
- 01H3SAMNWW2WDERPWN837DQ43R language "eng".
- 01H3SAMNWW2WDERPWN837DQ43R type conference.
- 01H3SAMNWW2WDERPWN837DQ43R hasPart 01HZEK64F0JMV9M7QNRX91Y1FP.pdf.
- 01H3SAMNWW2WDERPWN837DQ43R subject "Chemistry".
- 01H3SAMNWW2WDERPWN837DQ43R presentedAt urn:uuid:154bcced-60f8-40f8-9b22-4e6fc7277bab.
- 01H3SAMNWW2WDERPWN837DQ43R abstract "Chirality is a prevalent property found in nature, caused by the presence of a (carbon) chiral center in a molecule. Many molecules with different chirality greatly vary in their chemical properties, therefore the ability for separation and detection of these molecules is of utmost importance in the biomedical and pharmaceutical industries. (1) However, obtaining effective separation of chiral analytes in complex (biological or synthetic) samples requires high resolving power. Which can be theoretically achieved by Comprehensive two-dimensional liquid chromatography (LC x LC), as this technique would allow for a large increase in peak capacity per unit of time. However finding appropriate solvents for the second dimension might be difficult. The slow speed of chiral separations, on the other hand, has hampered the use of chiral stationary phases as the second dimension in 2D-LC. (2,3,4) In this study, the enantioselective separation of a wide range of medicinal substances (log p: 0.9-4.1) is evaluated using a combination of temperature-responsive and reversed-phase chiral liquid chromatography. Temperature-responsive liquid chromatography (TRLC) in the first dimension enables analysis in purely aqueous conditions, allowing for complete (and more general) focusing of organic solutes prior to second-dimension separation. (2) By combining this with small particle (sub-2 micron) based chiral stationary phases as the second dimension in TRLCxChiral-RPLC, a chiral screening platform may be built, which in principle has a lot of potential for tackling chiral screening challenges. (4)".
- 01H3SAMNWW2WDERPWN837DQ43R author 040449A4-F0EF-11E1-A197-91C894A0A6B4.
- 01H3SAMNWW2WDERPWN837DQ43R author 632b74a5-8bf7-11ea-af65-8e354b5490af.
- 01H3SAMNWW2WDERPWN837DQ43R author F52D4724-F0ED-11E1-A9DE-61C894A0A6B4.
- 01H3SAMNWW2WDERPWN837DQ43R dateCreated "2023-06-25T13:07:09Z".
- 01H3SAMNWW2WDERPWN837DQ43R dateModified "2024-11-27T23:58:35Z".
- 01H3SAMNWW2WDERPWN837DQ43R name "Hyphenation of temperature-responsive chromatography and ultrafast chiral chromatography as a generic comprehensive two-dimensional method for the analysis of chiral pharmaceuticals".
- 01H3SAMNWW2WDERPWN837DQ43R pagination urn:uuid:212d7d65-edf4-4625-ac44-15af5b2741df.
- 01H3SAMNWW2WDERPWN837DQ43R sameAs LU-01H3SAMNWW2WDERPWN837DQ43R.
- 01H3SAMNWW2WDERPWN837DQ43R sourceOrganization urn:uuid:51acdf7b-db9e-47f7-9144-d8fb2b82d130.
- 01H3SAMNWW2WDERPWN837DQ43R type C3.