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- 01H4FX982G10YFT2ZY48ZWF4VK classification C3.
- 01H4FX982G10YFT2ZY48ZWF4VK date "2023".
- 01H4FX982G10YFT2ZY48ZWF4VK language "eng".
- 01H4FX982G10YFT2ZY48ZWF4VK type conference.
- 01H4FX982G10YFT2ZY48ZWF4VK subject "Medicine and Health Sciences".
- 01H4FX982G10YFT2ZY48ZWF4VK subject "Veterinary Sciences".
- 01H4FX982G10YFT2ZY48ZWF4VK doi "10.1111/jvp.13175".
- 01H4FX982G10YFT2ZY48ZWF4VK issn "0140-7783".
- 01H4FX982G10YFT2ZY48ZWF4VK issn "1365-2885".
- 01H4FX982G10YFT2ZY48ZWF4VK issue "Supplement 1".
- 01H4FX982G10YFT2ZY48ZWF4VK presentedAt urn:uuid:9a0feb90-9bf3-4f1e-9316-511b1f43deba.
- 01H4FX982G10YFT2ZY48ZWF4VK volume "46".
- 01H4FX982G10YFT2ZY48ZWF4VK abstract "Objectives: Antibiotics are the cornerstone in the treatment of sepsis. Microdialysis (MD) data in adults suggest an impaired antibiotic tissue penetration in the case of sepsis. Tissue pharmacokinetics (PK) remain largely understudied in children. Juvenile pig models have proven to provide an accurate prediction of PK behavior in pediatric patients. This study aimed to investigate the influence of sepsis on the tissue penetration of piperacillin (PIP) - tazobactam (TAZ) in a piglet model. Methods: In 16 piglets, PIP-TAZ was administered over 4 days (75 mg/kg IV over 30 minutes, 6h dosing interval). Blood and MD samples (muscle) were collected in first-dose and steady-state (>24h) conditions. On day 3 and 4, in 10 piglets a continuous lipopolysaccharide (LPS) infusion was administered to induce a septic state. In the 6 control animals (no LPS) time effects during the study period were evaluated. Non-compartmental PK analysis was used to quantify the tissue penetration (Area Under the concentration-time Curve (AUC) ratio tissue/plasma). The AUC ratios were pairwise compared between the healthy and septic states in each piglet, data are reported as mean ± SD. The population pharmacokinetic analysis is ongoing. Results will be presented at the conference. Results: For PIP, the AUC ratio in first-dose conditions was significantly lower in the septic state (0.84 ± 0.22) compared to the healthy baseline measurement (1.06 ± 0.46) (P = 0.042). In steady-state conditions, comparable results were found with an AUC ratio of 0.80 ± 0.22 in the septic state and 1.09 ± 0.27 during baseline (p=0.009). Comparable results for TAZ were observed. There were no time effects observed in the control group. Conclusion: In this juvenile pig model, experimental endotoxemia impaired the PIP-TAZ tissue penetration. The results of this study warrant further research into the tissue PK of septic children to optimize antibiotic dosing in this population. Correlating the results of this study with future clinical data could endorse the applicability of the piglet model for drug research in septic children.".
- 01H4FX982G10YFT2ZY48ZWF4VK author 00D24390-F0EE-11E1-A9DE-61C894A0A6B4.
- 01H4FX982G10YFT2ZY48ZWF4VK author 03EFD394-F0EE-11E1-A9DE-61C894A0A6B4.
- 01H4FX982G10YFT2ZY48ZWF4VK author 07A3C8FA-F0EF-11E1-A197-91C894A0A6B4.
- 01H4FX982G10YFT2ZY48ZWF4VK author F4129F7E-F0ED-11E1-A9DE-61C894A0A6B4.
- 01H4FX982G10YFT2ZY48ZWF4VK author F50F7AE6-F0ED-11E1-A9DE-61C894A0A6B4.
- 01H4FX982G10YFT2ZY48ZWF4VK dateCreated "2023-07-04T07:36:15Z".
- 01H4FX982G10YFT2ZY48ZWF4VK dateModified "2024-12-12T17:51:28Z".
- 01H4FX982G10YFT2ZY48ZWF4VK name "Antibiotic tissue penetration in the septic piglet versus the child : lessons learnt from microdialysis".
- 01H4FX982G10YFT2ZY48ZWF4VK pagination urn:uuid:8a76b1c3-24b3-421d-b8bc-3a401a72c7d3.
- 01H4FX982G10YFT2ZY48ZWF4VK publisher urn:uuid:d1f477a7-6459-422a-b6a1-f59a4a1c8111.
- 01H4FX982G10YFT2ZY48ZWF4VK sameAs LU-01H4FX982G10YFT2ZY48ZWF4VK.
- 01H4FX982G10YFT2ZY48ZWF4VK sourceOrganization urn:uuid:33afa898-a355-4af4-9a1f-20bbdd59176d.
- 01H4FX982G10YFT2ZY48ZWF4VK sourceOrganization urn:uuid:3c56134f-8582-4432-aace-aaf018781361.
- 01H4FX982G10YFT2ZY48ZWF4VK sourceOrganization urn:uuid:5b566c8d-761f-4103-acf6-f07898db3805.
- 01H4FX982G10YFT2ZY48ZWF4VK sourceOrganization urn:uuid:e9466b2a-9a80-4c1d-ae0b-68e5f241fd45.
- 01H4FX982G10YFT2ZY48ZWF4VK type C3.