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- 01HA4CV4D1HY6DFJ636VWSCG7M classification C3.
- 01HA4CV4D1HY6DFJ636VWSCG7M date "2022".
- 01HA4CV4D1HY6DFJ636VWSCG7M language "eng".
- 01HA4CV4D1HY6DFJ636VWSCG7M type conference.
- 01HA4CV4D1HY6DFJ636VWSCG7M hasPart 01HBBGBZ5Q6KP734W9DF4CAWJ8.pdf.
- 01HA4CV4D1HY6DFJ636VWSCG7M subject "Biology and Life Sciences".
- 01HA4CV4D1HY6DFJ636VWSCG7M subject "Medicine and Health Sciences".
- 01HA4CV4D1HY6DFJ636VWSCG7M presentedAt urn:uuid:5a32a422-f552-4a20-96ee-fc01a2ab3718.
- 01HA4CV4D1HY6DFJ636VWSCG7M abstract "Introduction: In radiology, low X-ray energies (<120 kV) are used to obtain an optimal image while in radiotherapy, higher X-ray energies (MeV) are being used to irradicate tumor tissue. Within the energy range of 0.1- 6 MeV, the radiobiological effectiveness (RBE) has been stated as equal to 1. However, the energy deposition of X-rays shows differences in function of their energy spectrum, which might lead to changes in biological responses. Therefore, in this study we compare the DNA damage response (DDR) in peripheral blood lymphocytes (PBLs) exposed to different X-ray beam qualities and quantities. Methods: The DDR was evaluated by the γ-H2AX foci assay, the cytokinesis-block micronucleus assay and a SYTOX-based cell death assay in peripheral blood lymphocytes exposed to X-rays. Cells were irradiated in T25 flasks with a 220 kV X-ray research cabinet (SARRP, X-Strahl) or a 6 MV X-ray Linear accelerator (Elekta). Three main physical parameters were investigated: beam energy (V), mean photon energy (eV) and dose-rate (Gy/min). The addition of Cu filtration influenced the mean photon energy at the SARRP while dose-rates were varied by adjusting tube current for 220 kV X-rays (0,33-3 Gy/min) and by adjusting water-phantom depth in the 6 MV set-up (3-6 Gy/min). Results: The RBE of 220 kV X-rays compared to 6MV X-rays was higher than 1. When an identical beam energy was filtered to increase the mean photon energy, the RBE decreased. Within the tested dose rate ranges no specific effects were observed. The DDR is influenced by the beam energy and mean photon energies. this study demonstrates that its is crucial to consider and report these physical parameters in radiobiological experiments.".
- 01HA4CV4D1HY6DFJ636VWSCG7M author 53027602-6888-11E5-AD70-3415B5D1D7B1.
- 01HA4CV4D1HY6DFJ636VWSCG7M author B5F856BE-10F6-11E3-9BFC-607B10BDE39D.
- 01HA4CV4D1HY6DFJ636VWSCG7M author F475A11E-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HA4CV4D1HY6DFJ636VWSCG7M author F5FE1ED0-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HA4CV4D1HY6DFJ636VWSCG7M author F6642C16-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HA4CV4D1HY6DFJ636VWSCG7M author F6DD7E18-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HA4CV4D1HY6DFJ636VWSCG7M author FABBC2BC-9285-11E7-BDF5-1B0FAE28A064.
- 01HA4CV4D1HY6DFJ636VWSCG7M dateCreated "2023-09-12T09:51:28Z".
- 01HA4CV4D1HY6DFJ636VWSCG7M dateModified "2024-10-29T17:58:50Z".
- 01HA4CV4D1HY6DFJ636VWSCG7M name "The DNA damage response of peripheral blood lymphocytes exposed to X-rays with different beam qualities and quantities".
- 01HA4CV4D1HY6DFJ636VWSCG7M pagination urn:uuid:99517a45-4782-4ab9-b5bd-fbe616d2c472.
- 01HA4CV4D1HY6DFJ636VWSCG7M publisher urn:uuid:859dabff-7f89-47fb-8534-ca15fa86520a.
- 01HA4CV4D1HY6DFJ636VWSCG7M sameAs LU-01HA4CV4D1HY6DFJ636VWSCG7M.
- 01HA4CV4D1HY6DFJ636VWSCG7M sourceOrganization urn:uuid:d8d76077-546d-4b0c-a18a-db7724a84e11.
- 01HA4CV4D1HY6DFJ636VWSCG7M type C3.