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- 01HDGY5ZXR0DPRJ4MGS6VY1J5C classification C3.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C date "2023".
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C language "eng".
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C type conference.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C hasPart 01HM96Q77SQGBSPFG6247TNF2M.pdf.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C hasPart 01HM97FJZ16VM7XBNXARS8PSVN.pdf.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C subject "Chemistry".
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C presentedAt urn:uuid:b61af1f0-791a-4794-b906-37e85749548d.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C abstract "Many lanthanide complexes have unique chemical and physical properties, offering utilization in a wide range of applications, especially in biology and medicine. Complexes based on a DOTA ligand (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and its modifications are clinically used due to their exceptional stability (MRI imaging, targeted radionuclide therapy) [1]. In addition, introduction of other functional groups or bridges to the DOTA ligand instead of acetates enhances the possibilities for applications, such as incorporation of organic antennas for photoluminescence. One of the interesting molecules to study with lanthanides is dppz (dipyrido[3,2-a:2’,3’-c]phenazine). Dppz is ideally suited for sensitization of Nd3+, Er3+ and Yb3+ ions [2], which are all emitting in the near-infrared (NIR) region. Compared to the visible region, materials emitting in the NIR have advantages in being less harmful to biological tissue as well as better transparency of the tissue. Hence, together with the known capability of dppz to intercalate into DNA [3], novel DOTA-like Ln-complexes involving this dppz moiety could result in a new class of stable and water-soluble molecular probes for biomedical imaging. In our current work we present synthesis of a new DOTA-like ligand, preparation of Ln-complexes, their crystallographic study and photoluminescence properties. Obtained complexes are weakly soluble in water and are showing clear interaction with the model calf-thymus DNA, what makes them promising agents for biomedical applications. [1] Stasiuk, G.J.; Long, N.J., Chem. Commun., 2013, 49, 2732. [2] Bünzli, J.-C.G., Chem. Rev., 2010, 110, 2729–2755. [3] McQuaid, K.T.; Cardin, C.J., Adv. Inorg. Chem., 2020, 75, 393–424".
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C author 31FBC57C-F0EE-11E1-A9DE-61C894A0A6B4.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C author 3B0D5FAE-F0EE-11E1-A9DE-61C894A0A6B4.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C author 3F144230-B519-11E7-9A05-06D6AD28A064.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C author 74a64b83-64e1-11eb-bd51-d1119816c694.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C author urn:uuid:a78c503a-d19f-480a-ab12-e8d14725522c.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C author urn:uuid:f939230a-250e-4354-9cf1-b8fad3cd7c47.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C dateCreated "2023-10-24T13:32:28Z".
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C dateModified "2024-10-29T18:30:53Z".
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C name "Novel luminescent dipyridophenazine-lanthanide complexes for DNA interaction".
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C pagination urn:uuid:6c96b434-b880-4e91-905c-d556b0958a80.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C sameAs LU-01HDGY5ZXR0DPRJ4MGS6VY1J5C.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C sourceOrganization urn:uuid:1c11be9a-40e6-41ec-9916-01c015d1780e.
- 01HDGY5ZXR0DPRJ4MGS6VY1J5C type C3.