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- 01HEHW3D1NJJM67W7ZCRNQXYNF classification C3.
- 01HEHW3D1NJJM67W7ZCRNQXYNF date "2023".
- 01HEHW3D1NJJM67W7ZCRNQXYNF language "eng".
- 01HEHW3D1NJJM67W7ZCRNQXYNF type conference.
- 01HEHW3D1NJJM67W7ZCRNQXYNF hasPart 01HEHW7CAAJD591C3X0BCGT5VV.pdf.
- 01HEHW3D1NJJM67W7ZCRNQXYNF subject "Biology and Life Sciences".
- 01HEHW3D1NJJM67W7ZCRNQXYNF subject "Chemistry".
- 01HEHW3D1NJJM67W7ZCRNQXYNF subject "Technology and Engineering".
- 01HEHW3D1NJJM67W7ZCRNQXYNF presentedAt urn:uuid:ef8b59d8-4162-4800-b15c-9ce01b4d776a.
- 01HEHW3D1NJJM67W7ZCRNQXYNF abstract "The microbial production of new compounds of interest has increased rapidly since the rise of synthetic biology. Both the introduction of new pathways and the tweaking of existing ones allow to regulate the flux towards the end product of interest. However, often growth and production are competing for the same resources. Additionally, the introduced heterologous genes and their corresponding protein product can lead to toxicity for the cells, thereby hampering growth. Therefore, it might be more beneficial to separate the growth and production in time. The most well-known and straightforward manner to obtain this is by the use of inducible promoters. Unfortunately, the cost and sometimes toxicity of the inducers impede its industrial application. An elegant solution for this can be found by drawing inspiration from natural cell-cell communication systems, such as quorum sensing. In nature, these systems are used to activate certain pathways once a high cell density is obtained, thereby forming the perfect starting point for creating automated switches between growth and production. By constructing different quorum sensing-based genetic circuits in E. coli and creating and characterising variant libraries of these circuits, we aim to expand the current toolbox of quorum sensing-based switches. To achieve these complex genetic circuits, a new quorum sensing-regulated promoter was engineered, requiring two different quorum sensing molecules for its activation.".
- 01HEHW3D1NJJM67W7ZCRNQXYNF author 1040E052-F0EE-11E1-A9DE-61C894A0A6B4.
- 01HEHW3D1NJJM67W7ZCRNQXYNF author 9F407F0C-5350-11E5-9A5E-1BFBB4D1D7B1.
- 01HEHW3D1NJJM67W7ZCRNQXYNF author F99A640E-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HEHW3D1NJJM67W7ZCRNQXYNF dateCreated "2023-11-06T08:31:02Z".
- 01HEHW3D1NJJM67W7ZCRNQXYNF dateModified "2024-07-09T15:43:10Z".
- 01HEHW3D1NJJM67W7ZCRNQXYNF name "Promoter engineering to create quorum sensing-based genetic circuits".
- 01HEHW3D1NJJM67W7ZCRNQXYNF pagination urn:uuid:c81545e4-f564-45bc-ad21-4aaee855f224.
- 01HEHW3D1NJJM67W7ZCRNQXYNF sameAs LU-01HEHW3D1NJJM67W7ZCRNQXYNF.
- 01HEHW3D1NJJM67W7ZCRNQXYNF sourceOrganization urn:uuid:52e76586-425e-4e10-8d4c-43d5a4588c4e.
- 01HEHW3D1NJJM67W7ZCRNQXYNF type C3.