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- 01HKWMVENDRSAXH8QM5E0QZDSS classification C3.
- 01HKWMVENDRSAXH8QM5E0QZDSS date "2023".
- 01HKWMVENDRSAXH8QM5E0QZDSS language "eng".
- 01HKWMVENDRSAXH8QM5E0QZDSS type conference.
- 01HKWMVENDRSAXH8QM5E0QZDSS subject "Chemistry".
- 01HKWMVENDRSAXH8QM5E0QZDSS subject "Technology and Engineering".
- 01HKWMVENDRSAXH8QM5E0QZDSS presentedAt urn:uuid:3c88ae62-97e2-4b2d-8bc7-b1e46094897c.
- 01HKWMVENDRSAXH8QM5E0QZDSS abstract "The "oxygen paradox" refers to the intricate interplay between two contrasting biological processes involving oxygen (O2) as a reactant. O2 is vital for aerobic metabolism, acting as a fuel for oxidative phosphorylation within mitochondria. However, an excessive supply of O2 can lead to the generation of reactive species that harm cellular health. Therefore, maintaining O2 homeostasis becomes crucial, requiring a delicate balance that prioritizes the former process while minimizing the latter. In earlier research, a hypothesis was proposed centered around specialized membrane invaginations called caveolae. These unique structures exhibit a curved morphology and are rich in cholesterol. It was postulated that caveolae play a pivotal role in regulating O2 levels within cells by efficiently absorbing O2 and attenuating its release to the mitochondria. However, the exact mechanism through which caveolae contribute to O2 buffering remains unclear, presenting an intriguing research question. To address this knowledge gap, our primary objective is to investigate how specific structural characteristics of caveolae, such as membrane curvature and cholesterol content, influence the local O2 abundance and membrane permeability. To accurately simulate a curved membrane resembling caveolae, we employed coarse grained molecular dynamics (MD) simulations. After conducting a comprehensive set of tests, we carefully selected one of the CG beads to serve as the CG O2 model. Liposomes of varying sizes were created to represent different levels of curvature, composed of phosphatidylcholine (POPC) and cholesterol. This approach allows us to observe associated changes in the O2 free energy profile and membrane permeability. By unraveling the influence of membrane curvature and cholesterol content on local O2 abundance and membrane permeability, we aim to deepen our understanding of the underlying mechanisms governing O2 homeostasis. Ultimately, this enhanced knowledge may pave the way for the development of novel therapeutic approaches targeting O2-related disorders and conditions.".
- 01HKWMVENDRSAXH8QM5E0QZDSS author 26929427-1621-11ea-82de-f6c25dc23e21.
- 01HKWMVENDRSAXH8QM5E0QZDSS author F7F4F4A2-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HKWMVENDRSAXH8QM5E0QZDSS dateCreated "2024-01-11T16:14:30Z".
- 01HKWMVENDRSAXH8QM5E0QZDSS dateModified "2024-10-29T18:32:21Z".
- 01HKWMVENDRSAXH8QM5E0QZDSS name "Exploring caveolae's role in oxygen 'buffering' through coarse-grained molecular dynamics".
- 01HKWMVENDRSAXH8QM5E0QZDSS publisher urn:uuid:f23ab8c7-a004-44ef-8257-ba9394c18fbf.
- 01HKWMVENDRSAXH8QM5E0QZDSS sameAs LU-01HKWMVENDRSAXH8QM5E0QZDSS.
- 01HKWMVENDRSAXH8QM5E0QZDSS sourceOrganization urn:uuid:12a3d7c1-5fee-4780-be4d-c1547f9dc9d1.
- 01HKWMVENDRSAXH8QM5E0QZDSS type C3.