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- 01HMVBWSRYKQ0H0HMP47XMN4VZ classification C3.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ date "2023".
- 01HMVBWSRYKQ0H0HMP47XMN4VZ language "eng".
- 01HMVBWSRYKQ0H0HMP47XMN4VZ type conference.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ hasPart 01HMVDAFD9CK6HJKYET74H4VNG.pdf.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ subject "Chemistry".
- 01HMVBWSRYKQ0H0HMP47XMN4VZ subject "Earth and Environmental Sciences".
- 01HMVBWSRYKQ0H0HMP47XMN4VZ presentedAt urn:uuid:92851848-baf4-4e4e-82f7-180343abb47b.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ abstract "The coastal environment, as part of "blue spaces," is known for its positive effects on human health and wellbeing. This study aims to investigate the expanded biogenics hypothesis, which proposes that bioactive components released by marine algae and aerosolized in Sea Spray Aerosol (SSA) could positively impact human health by inhibiting signaling pathways such as mTOR, Akt, or PI3K. In this study, we exposed human bronchial epithelial cells (BEAS-2B) to nine natural SSA samples collected from the same location over a one-year period, along with ambient coast aerosol samples, city aerosol samples, and positive control (mTOR inhibitor). The RNA expressions of each BEAS-2B cell line sample were quantified and compared across treatments to support the biogenics hypothesis at the molecular level under environmentally realistic conditions using field aerosol samples. This study found that the SSA exposure group had the highest number of differentially expressed genes (DEGs) across all treatment groups. The results demonstrated a seasonal variation in SSA exposure effects and DEG numbers strongly correlating with phytoplankton density. The mTOR pathway, previously reported to be regulated by SSA exposure, was also found to be affected in the study. This research contributes to understanding the complex relationship between SSA exposure effects, phytoplankton activity, and seasonal variation, providing insight into the potential positive health effects of SSA exposure and encouraging further research on the role of marine algae-derived bioactive compounds in human health.".
- 01HMVBWSRYKQ0H0HMP47XMN4VZ author 04269B04-F0EE-11E1-A9DE-61C894A0A6B4.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ author A13E6F80-315A-11E4-9133-910EB5D1D7B1.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ author C39E11F2-C9DF-11E9-8057-A3165707D3EF.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ author F427CAB6-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ author urn:uuid:ff19cf16-9276-4a75-8426-d6241b261be2.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ dateCreated "2024-01-23T14:34:24Z".
- 01HMVBWSRYKQ0H0HMP47XMN4VZ dateModified "2024-07-09T15:43:12Z".
- 01HMVBWSRYKQ0H0HMP47XMN4VZ name "Molecular insights into health effects of sea spray aerosol exposure under environmentally realistic conditions".
- 01HMVBWSRYKQ0H0HMP47XMN4VZ pagination urn:uuid:bcf5d261-1a61-4157-a183-4fae1fe76ea1.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ sameAs LU-01HMVBWSRYKQ0H0HMP47XMN4VZ.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ sourceOrganization urn:uuid:ba7f10f5-0921-4ebe-956f-7138bc25a688.
- 01HMVBWSRYKQ0H0HMP47XMN4VZ type C3.