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- 01HR7ERVBD6CNAMGQ3V1BHESDM classification A1.
- 01HR7ERVBD6CNAMGQ3V1BHESDM date "2023".
- 01HR7ERVBD6CNAMGQ3V1BHESDM language "eng".
- 01HR7ERVBD6CNAMGQ3V1BHESDM type journalArticle.
- 01HR7ERVBD6CNAMGQ3V1BHESDM hasPart 01HR7F9490NYKT5NFETDD9B5T0.pdf.
- 01HR7ERVBD6CNAMGQ3V1BHESDM subject "Medicine and Health Sciences".
- 01HR7ERVBD6CNAMGQ3V1BHESDM doi "10.1097/PRS.0000000000010386".
- 01HR7ERVBD6CNAMGQ3V1BHESDM issn "0032-1052".
- 01HR7ERVBD6CNAMGQ3V1BHESDM issn "1529-4242".
- 01HR7ERVBD6CNAMGQ3V1BHESDM issue "4".
- 01HR7ERVBD6CNAMGQ3V1BHESDM presentedAt urn:uuid:b1828f3b-d8f8-4c3b-b13c-93aedd4117d7.
- 01HR7ERVBD6CNAMGQ3V1BHESDM volume "152".
- 01HR7ERVBD6CNAMGQ3V1BHESDM abstract "Background:Nipple-sparing mastectomy (NSM) has evolved as a standard surgical option. The NSM complication rate remains high in large breasts. To reduce the risk of necrosis, several authors have proposed delayed procedures to enhance blood supply to the nipple-areola complex (NAC). The purpose of this study in a porcine model was to show adequate redirection of NAC perfusion by neoangiogenesis through circumareolar scars.Methods:Delayed two-staged NSM was simulated in 52 nipples (six pigs) with a 60-day interval. The nipples underwent a full-thickness, circumareolar incision onto the muscular fascia, with preservation of underlying glandular perforators. After 60 days, NSM was performed through a radial incision. A silicone sheet was introduced in the mastectomy plane to prevent NAC revascularization by wound bed imbibition. Digital color imaging was used to assess necrosis. Near-infrared fluorescence with indocyanine green was used to assess perfusion patterns and perfusion in real time.Results:No NAC necrosis was seen after 60 days' delay in any nipples. In all nipples, indocyanine green angiography showed complete alteration of the NAC vascular perfusion pattern from subjacent gland to a capillary fill following devascularization, exhibiting a predominant arteriolar capillary blush without distinct larger vessels.Conclusions:NAC delay reverses glandular perfusion to adequate dermal neovascularization. Neovascularization through full-thickness scars provides sufficient dermal perfusion after 60 days' delay. Identical staged delay in humans may be a surgically safe NSM option and could broaden therapeutic NSM indications in difficult breasts. Large clinical trials are necessary to provide identical results in human breasts.Clinical Relevance Statement:NAC delay reverses glandular perfusion to adequate dermal neovascularization. Neovascularization through full-thickness scars provides sufficient dermal perfusion after 60 days of delay. Identical staged delay in humans may be a surgically safe NSM option.".
- 01HR7ERVBD6CNAMGQ3V1BHESDM author F6019CD6-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HR7ERVBD6CNAMGQ3V1BHESDM author urn:uuid:0515bc77-6660-4842-a067-18f2c5177daa.
- 01HR7ERVBD6CNAMGQ3V1BHESDM author urn:uuid:0ff5a962-3d15-4148-be31-1758f608a313.
- 01HR7ERVBD6CNAMGQ3V1BHESDM author urn:uuid:39715a58-9dfb-43c3-9ecd-bf6a74341172.
- 01HR7ERVBD6CNAMGQ3V1BHESDM author urn:uuid:608895aa-aab2-40da-a34b-210e55c151bb.
- 01HR7ERVBD6CNAMGQ3V1BHESDM author urn:uuid:759eb4c0-d03c-445e-8b7c-a5deeb7eb679.
- 01HR7ERVBD6CNAMGQ3V1BHESDM author urn:uuid:ad123c6b-71c1-43e3-a41f-99f93c7b3b16.
- 01HR7ERVBD6CNAMGQ3V1BHESDM author urn:uuid:ae2e16f9-d080-4ac4-ae26-aeae4c2e5be6.
- 01HR7ERVBD6CNAMGQ3V1BHESDM author urn:uuid:ee8259af-61bd-4f72-9ad0-baaeeb2d825b.
- 01HR7ERVBD6CNAMGQ3V1BHESDM dateCreated "2024-03-05T14:02:39Z".
- 01HR7ERVBD6CNAMGQ3V1BHESDM dateModified "2024-12-12T20:17:02Z".
- 01HR7ERVBD6CNAMGQ3V1BHESDM name "Dermal nipple-areola complex perfusion through circumareolar scars : a delay model in two-stage nipple-sparing mastectomy".
- 01HR7ERVBD6CNAMGQ3V1BHESDM pagination urn:uuid:b0abf1bc-2bf5-4829-b815-186b6fe1ce55.
- 01HR7ERVBD6CNAMGQ3V1BHESDM publisher urn:uuid:35cd4377-55ec-4776-af55-37d6d2b7320c.
- 01HR7ERVBD6CNAMGQ3V1BHESDM sameAs LU-01HR7ERVBD6CNAMGQ3V1BHESDM.
- 01HR7ERVBD6CNAMGQ3V1BHESDM sourceOrganization urn:uuid:830d6701-1eb5-4994-84fb-7fba81a0b4b4.
- 01HR7ERVBD6CNAMGQ3V1BHESDM sourceOrganization urn:uuid:894beb62-f58a-4441-92e0-0acf9b2f4ce6.
- 01HR7ERVBD6CNAMGQ3V1BHESDM type A1.