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- 01HS1AFH7017BZFW3S455J0BHZ classification C3.
- 01HS1AFH7017BZFW3S455J0BHZ date "2023".
- 01HS1AFH7017BZFW3S455J0BHZ language "eng".
- 01HS1AFH7017BZFW3S455J0BHZ type conference.
- 01HS1AFH7017BZFW3S455J0BHZ hasPart 01HS1APNYR06V76Z4JT1RV54VK.pdf.
- 01HS1AFH7017BZFW3S455J0BHZ subject "Agriculture and Food Sciences".
- 01HS1AFH7017BZFW3S455J0BHZ subject "Medicine and Health Sciences".
- 01HS1AFH7017BZFW3S455J0BHZ presentedAt urn:uuid:4e48a696-97f7-4b4e-bd1a-5516a9156d6c.
- 01HS1AFH7017BZFW3S455J0BHZ abstract "Red and processed meat consumption is correlated with an increased risk for colorectal cancer (CRC). We hypothesized that such a chronic dietary pattern may alter CRC cells’ metabolic behavior and therefore influences cancer cell growth, survival, flexibility, i.e. the ability to switch between substrates, plasticity, i.e. the ability to process substrates in a different way. In this study, the impact of chronic exposure to dietary metabolites on in vitro CRC models was investigated. Specifically, the effect of butyrate, an anti-inflammatory compounds derived from fiber, and of hemin and kynurenine, potentially harmful metabolites derived from red and processed meat consumption, were assessed using HCT116 spheroids and murine intestinal organoids (wild type and APCf/+). Exposure of spheroids has shown promising results, for example, a combination treatment of meat-derived hemin and kynurenine induced higher basal glycolysis rates with a similar oxidative metabolism compared to untreated control spheroids, indicating more energetic cancer cells. Moreover, after glucose deprivation, the metabolic flexibility and plasticity were higher in the pretreated spheroids compared to the control, potentially supported by increased lipid metabolism and glutaminolysis. These observations suggest a role of meat digestion compounds in colorectal carcinogenesis by a direct effect on cell metabolism. Applying a similar approach and analysis on the organoid models gave insights in how cancer stage and genetic makeup of the cells influences the responses. A comparison of healthy (WT) and APCf/+ organoids revealed that this early-onset event of CRC induces changes in morphology, cell-cell adhesion parameters, and cytokine secretion levels. Moreover, alterations in organoid size, lipid storage, and glucose/lactate levels imply that meat metabolites may also affect the bioenergetics of healthy and pre-cancerous intestinal cells. Future experiments will focus on the metabolic changes in intestinal organoids exposed to dietary metabolites. In this way we want to elucidate how red meat consumption changes the cell metabolism and how to interfere with this. This will lead to a better understanding of the etiology of colorectal cancer and the role of diet herein.".
- 01HS1AFH7017BZFW3S455J0BHZ author 16797E84-F0EE-11E1-A9DE-61C894A0A6B4.
- 01HS1AFH7017BZFW3S455J0BHZ author 4B50209E-FC5C-11E1-8B8A-AC6710BDE39D.
- 01HS1AFH7017BZFW3S455J0BHZ author F4B233EA-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HS1AFH7017BZFW3S455J0BHZ author F5D0FA72-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HS1AFH7017BZFW3S455J0BHZ author F6996D04-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HS1AFH7017BZFW3S455J0BHZ author F7A30E30-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HS1AFH7017BZFW3S455J0BHZ author F8E8386A-F0ED-11E1-A9DE-61C894A0A6B4.
- 01HS1AFH7017BZFW3S455J0BHZ dateCreated "2024-03-15T15:07:54Z".
- 01HS1AFH7017BZFW3S455J0BHZ dateModified "2024-10-29T18:39:15Z".
- 01HS1AFH7017BZFW3S455J0BHZ name "Effect on colorectal cancer bioenergetics by chronic exposure to red meat metabolites".
- 01HS1AFH7017BZFW3S455J0BHZ pagination urn:uuid:cb19d698-30b1-49d4-b888-a72044c5b066.
- 01HS1AFH7017BZFW3S455J0BHZ sameAs LU-01HS1AFH7017BZFW3S455J0BHZ.
- 01HS1AFH7017BZFW3S455J0BHZ sourceOrganization urn:uuid:13336367-c7ef-49fe-ae2d-ad4185fdc9f9.
- 01HS1AFH7017BZFW3S455J0BHZ sourceOrganization urn:uuid:661feb1b-bb5a-4baf-b2f1-b6be0757a4b9.
- 01HS1AFH7017BZFW3S455J0BHZ sourceOrganization urn:uuid:8e900ec8-2c36-4c0b-93f0-e635e6a03829.
- 01HS1AFH7017BZFW3S455J0BHZ sourceOrganization urn:uuid:a05bdf66-9e8d-4ec1-93ce-48f4be75d876.
- 01HS1AFH7017BZFW3S455J0BHZ type C3.