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- 01J05WPVVH3DM8CPGQY6J1EVZG classification A1.
- 01J05WPVVH3DM8CPGQY6J1EVZG date "2024".
- 01J05WPVVH3DM8CPGQY6J1EVZG language "eng".
- 01J05WPVVH3DM8CPGQY6J1EVZG type journalArticle.
- 01J05WPVVH3DM8CPGQY6J1EVZG hasPart 01J05X5NDT5B8ZZYS0Z7QWSSCS.docx.
- 01J05WPVVH3DM8CPGQY6J1EVZG hasPart 01J0QQNEJE6V3H0MZ778N2XEBY.pdf.
- 01J05WPVVH3DM8CPGQY6J1EVZG subject "Biology and Life Sciences".
- 01J05WPVVH3DM8CPGQY6J1EVZG subject "Technology and Engineering".
- 01J05WPVVH3DM8CPGQY6J1EVZG doi "10.1021/acs.est.3c10868".
- 01J05WPVVH3DM8CPGQY6J1EVZG issn "0013-936X".
- 01J05WPVVH3DM8CPGQY6J1EVZG issn "1520-5851".
- 01J05WPVVH3DM8CPGQY6J1EVZG issue "23".
- 01J05WPVVH3DM8CPGQY6J1EVZG volume "58".
- 01J05WPVVH3DM8CPGQY6J1EVZG abstract "Nanoplastics (NPs) are omnipresent in the environment and contribute to human exposure. However, little is known regarding the long-term effects of NPs on human health. In this study, human intestinal Caco-2 cells were exposed to polystyrene nanoplastics (nanoPS) in an environmentally relevant concentration range (10(2)-10(9) particles/mL) under two realistic exposure scenarios. In the first scenario, cells were repeatedly exposed to nanoPS every 2 days for 12 days to study the long-term effects. In the second scenario, only nanoPS was added once and Caco-2 cells were cultured for 12 days to study the duration of the initial effects of NPs. Under repeated dosing, initial subtle effects on mitochondria induced by low concentrations would accrue over consistent exposure to nanoPS and finally lead to significant impairment of mitochondrial respiration, mitochondrial mass, and cell differentiation process at the end of prolonged exposure, accompanied by significantly increased glycolysis over the whole exposure period. Single dosing of nanoPS elicited transient effects on mitochondrial and glycolytic functions, as well as increased reactive oxygen species (ROS) production in the early phase of exposure, but the self-recovery capacity of cells mitigated these effects at intermediate culture times. Notably, secondary effects on glycolysis and ROS production were observed during the late culture period, while the cell differentiation process and mitochondrial mass were not affected at the end. These long-term effects are of crucial importance for comprehensively evaluating the health hazards arising from lifetime exposure to NPs, complementing the extensively observed acute effects associated with prevalent short-term exposure to high concentrations. Our study underlines the need to study the toxicity of NPs in realistic long-term exposure scenarios such as repeated dosing.".
- 01J05WPVVH3DM8CPGQY6J1EVZG author 04269B04-F0EE-11E1-A9DE-61C894A0A6B4.
- 01J05WPVVH3DM8CPGQY6J1EVZG author 21131B48-F0EE-11E1-A9DE-61C894A0A6B4.
- 01J05WPVVH3DM8CPGQY6J1EVZG author F427CAB6-F0ED-11E1-A9DE-61C894A0A6B4.
- 01J05WPVVH3DM8CPGQY6J1EVZG author F56DD06E-F0ED-11E1-A9DE-61C894A0A6B4.
- 01J05WPVVH3DM8CPGQY6J1EVZG author F6996D04-F0ED-11E1-A9DE-61C894A0A6B4.
- 01J05WPVVH3DM8CPGQY6J1EVZG author F7A30E30-F0ED-11E1-A9DE-61C894A0A6B4.
- 01J05WPVVH3DM8CPGQY6J1EVZG author ac3a7d33-9c93-11ef-97cb-fbef9491bed3.
- 01J05WPVVH3DM8CPGQY6J1EVZG dateCreated "2024-06-12T09:33:20Z".
- 01J05WPVVH3DM8CPGQY6J1EVZG dateModified "2024-12-12T21:14:03Z".
- 01J05WPVVH3DM8CPGQY6J1EVZG name "Probing long-term impacts : low-dose polystyrene nanoplastics exacerbate mitochondrial health and evoke secondary glycolysis via repeated and single dosing".
- 01J05WPVVH3DM8CPGQY6J1EVZG pagination urn:uuid:e8311d87-3233-4007-adfd-4b9d812a5606.
- 01J05WPVVH3DM8CPGQY6J1EVZG sameAs LU-01J05WPVVH3DM8CPGQY6J1EVZG.
- 01J05WPVVH3DM8CPGQY6J1EVZG sourceOrganization urn:uuid:24cdcbad-0d01-4033-a1fd-27442db06ca3.
- 01J05WPVVH3DM8CPGQY6J1EVZG sourceOrganization urn:uuid:b099b33e-5d59-4cc0-b514-2e28e567d40b.
- 01J05WPVVH3DM8CPGQY6J1EVZG sourceOrganization urn:uuid:e316a514-12d6-45f8-aa62-cfff2ef38a25.
- 01J05WPVVH3DM8CPGQY6J1EVZG type A1.