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- 01J06JQ7K0MESRHKPYCNBJ727V classification A1.
- 01J06JQ7K0MESRHKPYCNBJ727V date "2024".
- 01J06JQ7K0MESRHKPYCNBJ727V language "eng".
- 01J06JQ7K0MESRHKPYCNBJ727V type journalArticle.
- 01J06JQ7K0MESRHKPYCNBJ727V hasPart 01J086FZ4T4GTGJTWADHVGXZAB.pdf.
- 01J06JQ7K0MESRHKPYCNBJ727V subject "Medicine and Health Sciences".
- 01J06JQ7K0MESRHKPYCNBJ727V doi "10.1016/j.jpain.2024.01.336".
- 01J06JQ7K0MESRHKPYCNBJ727V issn "1526-5900".
- 01J06JQ7K0MESRHKPYCNBJ727V issn "1528-8447".
- 01J06JQ7K0MESRHKPYCNBJ727V issue "6".
- 01J06JQ7K0MESRHKPYCNBJ727V volume "25".
- 01J06JQ7K0MESRHKPYCNBJ727V abstract "Grey matter (GM) changes are often observed in people with chronic spinal pain, including those with chronic whiplash-associated disorders (CWAD). These GM adaptations may be reversed with treatment, at least partially. Pain neuroscience education combined with exercise (PNE+Exercise) is an effective treatment, but its neural underlying mechanisms still remain unexplored in CWAD. Here, we performed both cross-sectional and longitudinal voxel-based morphometry to i) identify potential GM alterations in people with CWAD (n=63) compared to age- and sex-matched pain-free controls (n=32) and ii) determine whether these GM alterations might be reversed following PNE+Exercise (compared to conventional physiotherapy). The cross-sectional whole-brain analysis revealed that individuals with CWAD had less GM volume in right and left dorsolateral prefrontal cortex (dlPFC) and left inferior temporal gyrus which was, in turn, associated with higher pain vigilance. Fifty individuals with CWAD and 29 pain-free controls were retained in the longitudinal analysis. GM in the right dlPFC increased after treatment in people with CWAD. Moreover, the longitudinal whole-brain analysis revealed that individuals with CWAD had decreases in GM volumes of the left and right central operculum and supramarginal after treatment. These changes were not specific to treatment modality and some were not observed in pain-free controls over time. Herewith, we provide the first evidence on how GM adaptations to CWAD respond to treatment.".
- 01J06JQ7K0MESRHKPYCNBJ727V author 09D71758-4778-11E9-98B5-94A45607D3EF.
- 01J06JQ7K0MESRHKPYCNBJ727V author 12086A86-F0EE-11E1-A9DE-61C894A0A6B4.
- 01J06JQ7K0MESRHKPYCNBJ727V author 25663088-2A65-11E9-8C42-1F325707D3EF.
- 01J06JQ7K0MESRHKPYCNBJ727V author 33B31244-F0EE-11E1-A9DE-61C894A0A6B4.
- 01J06JQ7K0MESRHKPYCNBJ727V author 34FE3F70-F0EE-11E1-A9DE-61C894A0A6B4.
- 01J06JQ7K0MESRHKPYCNBJ727V author F5BDF576-F0ED-11E1-A9DE-61C894A0A6B4.
- 01J06JQ7K0MESRHKPYCNBJ727V author urn:uuid:3f963e45-9c88-4814-a7e3-66b994fa593b.
- 01J06JQ7K0MESRHKPYCNBJ727V author urn:uuid:ab050817-5556-4206-8597-02affeba2338.
- 01J06JQ7K0MESRHKPYCNBJ727V author urn:uuid:ad6d723c-bbb8-4020-8d1e-e1e61c343532.
- 01J06JQ7K0MESRHKPYCNBJ727V dateCreated "2024-06-12T15:58:00Z".
- 01J06JQ7K0MESRHKPYCNBJ727V dateModified "2024-12-12T21:12:33Z".
- 01J06JQ7K0MESRHKPYCNBJ727V name "Gray matter adaptations to chronic pain in people with whiplash-associated disorders are partially reversed after treatment : a voxel-based morphometry study".
- 01J06JQ7K0MESRHKPYCNBJ727V pagination urn:uuid:7b512a50-5706-4779-b671-a480abcecfaf.
- 01J06JQ7K0MESRHKPYCNBJ727V sameAs LU-01J06JQ7K0MESRHKPYCNBJ727V.
- 01J06JQ7K0MESRHKPYCNBJ727V sourceOrganization urn:uuid:3f81a27a-a9c8-408a-a82c-86ccda490720.
- 01J06JQ7K0MESRHKPYCNBJ727V type A1.