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- 01JGXJDK2MH0GSRSR1ANP0K8J8 classification A1.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 date "2025".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 language "eng".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 type journalArticle.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 hasPart 01JGXJR6SD2WR6MPWQ3QMJ4GWG.pdf.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 hasPart 01JHQH4M6Y5B3JJPDYQ0BGTA07.pdf.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 subject "Medicine and Health Sciences".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 doi "10.1016/j.jconrel.2024.12.048".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 issn "0168-3659".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 issn "1873-4995".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 volume "378".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 abstract "Tumor fluid dynamics and drug delivery simulations in solid tumors are highly relevant topics in clinical oncology. The current study introduces a novel method combining computational fluid dynamics (CFD) modeling, quantitative magnetic resonance imaging (MRI; including dynamic contrast-enhanced (DCE) MRI and diffusion-weighted (DW) MRI), and a novel ex-vivo protocol to generate patient-specific models of solid tumors in four patients with peritoneal metastases. DCE-MRI data were analyzed using the extended Tofts model to estimate the spatial distribution of tumor capillary permeability using the Ktrans parameter. DW-MRI data analysis provided a 3D representation of drug diffusivity, and DW-MRI coupled to an ex-vivo measurement protocol informed the spatial heterogeneity of the hydraulic conductivity of tumor tissue. The patient-specific data were subsequently incorporated into a computational fluid dynamics (CFD) model to simulate individualized tumor perfusion and drug transport maps. The results on interstitial fluid flow demonstrated noticeable heterogeneity of interstitial fluid pressure and velocity within the tumor, along with heterogeneous drug penetration profiles among different tumors, even with a similar drug administration regimen.".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 author 0012AE7E-02ED-11E8-A726-D58012A95AF2.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 author 0BE4CA0A-F0EE-11E1-A9DE-61C894A0A6B4.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 author 34402fba-f9d7-11e9-9246-ced536015f62.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 author FE50E55E-F0ED-11E1-A9DE-61C894A0A6B4.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 dateCreated "2025-01-06T10:26:26Z".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 dateModified "2025-02-25T07:30:56Z".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 name "Image-guided patient-specific prediction of interstitial fluid flow and drug transport in solid tumors".
- 01JGXJDK2MH0GSRSR1ANP0K8J8 pagination urn:uuid:b7eaac77-3160-437f-a79f-4b3260d17fc9.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 sameAs LU-01JGXJDK2MH0GSRSR1ANP0K8J8.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 sourceOrganization urn:uuid:5ab69172-0baa-4143-a374-8b420a518fe9.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 sourceOrganization urn:uuid:619801b2-b2b1-4ce2-8903-9255e6b42672.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 sourceOrganization urn:uuid:f1668823-9802-4d3a-ab6d-3cdb462e7942.
- 01JGXJDK2MH0GSRSR1ANP0K8J8 type A1.