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- 01JH02SF2Z3E6Q9A4KESCHAP9V classification A1.
- 01JH02SF2Z3E6Q9A4KESCHAP9V date "2025".
- 01JH02SF2Z3E6Q9A4KESCHAP9V language "eng".
- 01JH02SF2Z3E6Q9A4KESCHAP9V type journalArticle.
- 01JH02SF2Z3E6Q9A4KESCHAP9V hasPart 01JH02Z5FNTS2QZMQ224961FH0.pdf.
- 01JH02SF2Z3E6Q9A4KESCHAP9V subject "Biology and Life Sciences".
- 01JH02SF2Z3E6Q9A4KESCHAP9V subject "Medicine and Health Sciences".
- 01JH02SF2Z3E6Q9A4KESCHAP9V subject "Physics and Astronomy".
- 01JH02SF2Z3E6Q9A4KESCHAP9V doi "10.1002/bem.22529".
- 01JH02SF2Z3E6Q9A4KESCHAP9V issn "0197-8462".
- 01JH02SF2Z3E6Q9A4KESCHAP9V issn "1521-186X".
- 01JH02SF2Z3E6Q9A4KESCHAP9V issue "1".
- 01JH02SF2Z3E6Q9A4KESCHAP9V volume "46".
- 01JH02SF2Z3E6Q9A4KESCHAP9V abstract "Occupational exposure limit values (ELVs) for body internal electric fields can be derived from thresholds for action potential generation. These thresholds can be calculated with electrostimulation models. The spatially extended nonlinear node model (SENN) is often used to determine such thresholds. Important parameters of these models are the membrane channel dynamics describing the ionic transmembrane currents as well as the temperature at which the models operate. This work compares action potential thresholds for five different membrane channel dynamics used with the SENN model. Furthermore, two more detailed double-cable models by Gaines et al. (MRG-Sensory and MRG-Motor) are also considered in this work. Thresholds calculated with the SENN model and the MRG models are compared for frequencies between 1 Hz and 100 kHz and temperatures at 22 degrees C and 37 degrees C. Results show that MRG thresholds are lower than SENN thresholds. Deriving alternative ELVs from these thresholds shows that the alternative ELVs can change significantly with different ion channel dynamics (up to a factor of 22). Using the double cable model could lead to approximately ten times lower alternative exposure limit values. On the contrary, using the SENN model with different membrane channel dynamics could also lead to higher alternative exposure limit values. Therefore, future exposure guidelines should take the influence of different electrostimulation models into account when deriving ELVs.".
- 01JH02SF2Z3E6Q9A4KESCHAP9V author 345BFDBA-1CC0-11E3-A8AA-4B8E10BDE39D.
- 01JH02SF2Z3E6Q9A4KESCHAP9V author 36D52C00-F0EE-11E1-A9DE-61C894A0A6B4.
- 01JH02SF2Z3E6Q9A4KESCHAP9V author 4AC86022-697D-11E6-9EE4-95CFB4D1D7B1.
- 01JH02SF2Z3E6Q9A4KESCHAP9V author F5FAC172-F0ED-11E1-A9DE-61C894A0A6B4.
- 01JH02SF2Z3E6Q9A4KESCHAP9V author F7B63492-F0ED-11E1-A9DE-61C894A0A6B4.
- 01JH02SF2Z3E6Q9A4KESCHAP9V author urn:uuid:2fb3c7d8-8465-41b8-9ed5-773cb02cd092.
- 01JH02SF2Z3E6Q9A4KESCHAP9V author urn:uuid:4c3f20a9-3891-45fe-838f-80d5f6b8daea.
- 01JH02SF2Z3E6Q9A4KESCHAP9V dateCreated "2025-01-07T09:51:01Z".
- 01JH02SF2Z3E6Q9A4KESCHAP9V dateModified "2025-01-17T08:30:27Z".
- 01JH02SF2Z3E6Q9A4KESCHAP9V name "Action potential threshold variability for different electrostimulation models and its potential impact on occupational exposure limit values".
- 01JH02SF2Z3E6Q9A4KESCHAP9V pagination urn:uuid:272912cc-3d58-458d-ae50-8f1fa6cb9797.
- 01JH02SF2Z3E6Q9A4KESCHAP9V sameAs LU-01JH02SF2Z3E6Q9A4KESCHAP9V.
- 01JH02SF2Z3E6Q9A4KESCHAP9V sourceOrganization urn:uuid:038b8b28-c2c5-4a17-8ec0-92bc8dac8d1d.
- 01JH02SF2Z3E6Q9A4KESCHAP9V sourceOrganization urn:uuid:505ef46e-11d7-4f0f-b1b4-4738e2d1d5ec.
- 01JH02SF2Z3E6Q9A4KESCHAP9V sourceOrganization urn:uuid:8abb2f7e-7416-4a8f-9c08-90950d99780e.
- 01JH02SF2Z3E6Q9A4KESCHAP9V type A1.