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- 01JHFVB4EGKBXA6R2W6QBN5XAW classification A1.
- 01JHFVB4EGKBXA6R2W6QBN5XAW date "2024".
- 01JHFVB4EGKBXA6R2W6QBN5XAW language "eng".
- 01JHFVB4EGKBXA6R2W6QBN5XAW type journalArticle.
- 01JHFVB4EGKBXA6R2W6QBN5XAW hasPart 01JJ9QW01VPSM9KM83WC6XP5E7.pdf.
- 01JHFVB4EGKBXA6R2W6QBN5XAW subject "Biology and Life Sciences".
- 01JHFVB4EGKBXA6R2W6QBN5XAW subject "Veterinary Sciences".
- 01JHFVB4EGKBXA6R2W6QBN5XAW doi "10.1080/19490976.2024.2399215".
- 01JHFVB4EGKBXA6R2W6QBN5XAW issn "1949-0976".
- 01JHFVB4EGKBXA6R2W6QBN5XAW issn "1949-0984".
- 01JHFVB4EGKBXA6R2W6QBN5XAW issue "1".
- 01JHFVB4EGKBXA6R2W6QBN5XAW volume "16".
- 01JHFVB4EGKBXA6R2W6QBN5XAW abstract "Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in humans and animals, induced by enterotoxins produced by these pathogens. Despite the crucial role of neutrophils in combatting bacterial infections, our understanding of how enterotoxins impact neutrophil function is limited. To address this knowledge gap, we used heat-labile enterotoxin (LT) and heat-stable enterotoxin a (STa) to investigate their impact on the effector functions of neutrophils. Our study reveals that pSTa does not exert any discernible effect on the function of neutrophils. In contrast, LT altered the migration and phagocytosis of neutrophils and induced the production of inflammatory factors via activation of cAMP/PKA and ERK1/2 signalling. LT also attenuated the release of neutrophil extracellular traps by neutrophils via the PKA signalling pathway. Our findings provide novel insights into the impact of LT on neutrophil function, shedding light on the underlying mechanisms that govern its immunoregulatory effects. This might help ETEC in subverting the immune system and establishing infection.".
- 01JHFVB4EGKBXA6R2W6QBN5XAW author 13B2F13A-F0EE-11E1-A9DE-61C894A0A6B4.
- 01JHFVB4EGKBXA6R2W6QBN5XAW author 3457D0F4-F0EE-11E1-A9DE-61C894A0A6B4.
- 01JHFVB4EGKBXA6R2W6QBN5XAW author 4A7265B0-FC5C-11E1-8B8A-AC6710BDE39D.
- 01JHFVB4EGKBXA6R2W6QBN5XAW author F4500670-F0ED-11E1-A9DE-61C894A0A6B4.
- 01JHFVB4EGKBXA6R2W6QBN5XAW author F7825820-F0ED-11E1-A9DE-61C894A0A6B4.
- 01JHFVB4EGKBXA6R2W6QBN5XAW author f78d59b7-23a8-11eb-8450-ab20376d8305.
- 01JHFVB4EGKBXA6R2W6QBN5XAW dateCreated "2025-01-13T12:48:42Z".
- 01JHFVB4EGKBXA6R2W6QBN5XAW dateModified "2025-01-28T07:28:07Z".
- 01JHFVB4EGKBXA6R2W6QBN5XAW name "Enterotoxigenic Escherichia coli heat labile enterotoxin affects neutrophil effector functions via cAMP/PKA/ERK signaling".
- 01JHFVB4EGKBXA6R2W6QBN5XAW pagination urn:uuid:6058fb77-42da-42a6-8a30-0429ed35e9fd.
- 01JHFVB4EGKBXA6R2W6QBN5XAW sameAs LU-01JHFVB4EGKBXA6R2W6QBN5XAW.
- 01JHFVB4EGKBXA6R2W6QBN5XAW sourceOrganization urn:uuid:9a9ad4a7-8193-47d1-9647-fc4a5f35fe94.
- 01JHFVB4EGKBXA6R2W6QBN5XAW type A1.