Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1004359#aggregation> ?p ?o. }
Showing items 1 to 46 of
46
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B192046.
- aggregation creator B192047.
- aggregation creator B192048.
- aggregation creator B192049.
- aggregation creator B192050.
- aggregation creator B192051.
- aggregation creator B192052.
- aggregation creator B192053.
- aggregation creator B192054.
- aggregation creator B192055.
- aggregation creator B192056.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 1004359.bibtex.
- aggregation hasFormat 1004359.csv.
- aggregation hasFormat 1004359.dc.
- aggregation hasFormat 1004359.didl.
- aggregation hasFormat 1004359.doc.
- aggregation hasFormat 1004359.json.
- aggregation hasFormat 1004359.mets.
- aggregation hasFormat 1004359.mods.
- aggregation hasFormat 1004359.rdf.
- aggregation hasFormat 1004359.ris.
- aggregation hasFormat 1004359.txt.
- aggregation hasFormat 1004359.xls.
- aggregation hasFormat 1004359.yaml.
- aggregation isPartOf urn:issn:1465-7392.
- aggregation language "eng".
- aggregation publisher "NATURE PUBLISHING GROUP".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis".
- aggregation abstract "MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness. miR-9-mediated E-cadherin downregulation results in the activation of beta-catenin signalling, which contributes to upregulated expression of the gene encoding vascular endothelial growth factor (VEGF); this leads, in turn, to increased tumour angiogenesis. Overexpression of miR-9 in otherwise non-metastatic breast tumour cells enables these cells to form pulmonary micrometastases in mice. Conversely, inhibiting miR-9 by using a 'miRNA sponge' in highly malignant cells inhibits metastasis formation. Expression of miR-9 is activated by MYC and MYCN, both of which directly bind to the mir-9-3 locus. Significantly, in human cancers, miR-9 levels correlate with MYCN amplification, tumour grade and metastatic status. These findings uncover a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasis-suppressing protein E-cadherin.".
- aggregation authorList BK452116.
- aggregation endPage "U52".
- aggregation issue "3".
- aggregation startPage "247".
- aggregation volume "12".
- aggregation aggregates 1008091.
- aggregation isDescribedBy 1004359.
- aggregation similarTo ncb2024.
- aggregation similarTo LU-1004359.