Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1006614#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B505694.
- aggregation creator B505695.
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- aggregation creator person.
- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 1006614.bibtex.
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- aggregation isPartOf urn:issn:0003-4975.
- aggregation language "eng".
- aggregation publisher "Elsevier Inc".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Tight Glycemic Control Protects the Myocardium and Reduces Inflammation in Neonatal Heart Surgery".
- aggregation abstract "Neonatal cardiac surgery evokes hyperglycemia and a systemic inflammatory response. Hyperglycemia is associated with intensified inflammation and adverse outcome in critically ill children and in pediatric cardiac surgery. Recently we demonstrated that tight glycemic control (TGC) reduced morbidity and mortality of critically ill children. Experimental data suggest that insulin protects the myocardium in the setting of ischemia-reperfusion injury, but this benefit could be blunted by coinciding hyperglycemia. We hypothesized that insulin-titrated TGC, initiated prior to myocardial ischemia and reperfusion, protects the myocardium and attenuates the inflammatory response after neonatal cardiac surgery. Methods This is a prospective randomized study at a university hospital. Fourteen neonates were randomized to intraoperative and postoperative conventional insulin therapy or TGC. Study endpoints were effects on myocardial damage and function; inflammation, endothelial activation, and clinical outcome parameters. Results Tight glycemic control significantly reduced circulating levels of cardiac troponin-I (p = 0.009), heart fatty acid-binding protein (p = 0.01), B-type natriuretic peptide (p = 0.002), and the need for vasoactive support (p = 0.008). The TGC suppressed the rise of the proinflammatory cytokines interleukin-6 (p = 0.02) and interleukin-8 (p = 0.05), and reduced the postoperative increase in C-reactive protein (p = 0.04). Myocardial concentrations of Akt, endothelial nitric-oxide synthase, and their phosphorylated forms were not different between groups. Conclusions In neonates undergoing cardiac surgery, intraoperative and postoperative TGC protects the myocardium and reduces the inflammatory response. This appears not to be mediated by an early, direct insulin signaling effect, but may rather be due to independent effects of preventing hyperglycemia during reperfusion".
- aggregation authorList BK848109.
- aggregation endPage "30".
- aggregation issue "1".
- aggregation startPage "22".
- aggregation volume "90".
- aggregation aggregates 1006639.
- aggregation isDescribedBy 1006614.
- aggregation similarTo j.athoracsur.2010.03.093.
- aggregation similarTo LU-1006614.