Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1021765#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B224898.
- aggregation creator B224899.
- aggregation creator B224900.
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- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 1021765.bibtex.
- aggregation hasFormat 1021765.csv.
- aggregation hasFormat 1021765.dc.
- aggregation hasFormat 1021765.didl.
- aggregation hasFormat 1021765.doc.
- aggregation hasFormat 1021765.json.
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- aggregation hasFormat 1021765.mods.
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- aggregation hasFormat 1021765.txt.
- aggregation hasFormat 1021765.xls.
- aggregation hasFormat 1021765.yaml.
- aggregation isPartOf urn:issn:2041-4889.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria".
- aggregation abstract "Autophagy and apoptosis are two important and interconnected stress-response mechanisms. However, the molecular interplay between these two pathways is not fully understood. To study the fate and function of autophagic proteins at the onset of apoptosis, we used a cellular model system in which autophagy precedes apoptosis. IL-3 depletion of Ba/F3 cells caused caspase (casp)-mediated cleavage of Beclin-1 and PI3KC3, two crucial components of the autophagy-inducing complex. We identified two casp cleavage sites in Beclin-1, TDVD133 and DQLD149, cleavage at which yields fragments lacking the autophagyinducing capacity. Noteworthy, the C-terminal fragment, Beclin-1-C, localized predominantly at the mitochondria and sensitized the cells to apoptosis. Moreover, on isolated mitochondria, recombinant Beclin-1-C was able to induce the release of proapoptotic factors. These findings point to a mechanism by which casp-dependent generation of Beclin-1-C creates an amplifying loop enhancing apoptosis upon growth factor withdrawal.".
- aggregation authorList BK492254.
- aggregation volume "1".
- aggregation aggregates 2937411.
- aggregation isDescribedBy 1021765.
- aggregation similarTo cddis.2009.16.
- aggregation similarTo LU-1021765.