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- aggregation classification "A1".
- aggregation creator B173986.
- aggregation creator B173987.
- aggregation creator B173988.
- aggregation creator person.
- aggregation creator person.
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- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 1029782.bibtex.
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- aggregation isPartOf urn:issn:1478-3223.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer".
- aggregation abstract "Background and aims: There is a demand for serum markers that can routinely assess the progression of liver cancer. DENA (diethylnitrosamine), a hepatocarcinogen, is commonly used in an experimental mouse model to induce liver cancer that closely mimics a subclass of human hepatocellular carcinoma (HCC). However, blood monitoring of the progression of HCC in mouse model has not yet been achieved. In this report, we studied glycomics during the development of mouse HCC induced by DENA. Methods: Mouse HCC was induced by DENA. Serum N-glycans were profiled using the sequencer assisted–Fluorophore-assisted carbohydrate electrophoresis technique developed in our laboratory. Possible alteration in the transcription of genes relevant to the synthesis of the changed glycans was analysed by realtime polymerase chain reaction. Results: In comparison with the control mice that received the same volume of saline, a tri-antennary glycan (peak 8) and a biantennary glycan (peak 4) in serum total glycans of DENA mice increased gradually but significantly during progression of liver cancer, whereas a corefucosylated biantennary glycan (peak 6) decreased. Expression of a-1,6- fucosyltransferase 8 (Fut8), which is responsible for core fucosylation, decreased in the liver of DENA mice compared with that of age-matched control mice. Likewise, the expression level of Mgat4a, which is responsible for tri-antennary, significantly increased in the liver of DENA mice (Po0.001). Conclusions: The changes of N-glycan levels in the serum could be used as a biomarker to monitor the progress of HCC and to follow up the treatment of liver tumours in this DENA mouse model.".
- aggregation authorList BK426961.
- aggregation endPage "1228".
- aggregation issue "8".
- aggregation startPage "1221".
- aggregation volume "30".
- aggregation aggregates 2937429.
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- aggregation similarTo j.1478-3231.2010.02279.x.
- aggregation similarTo LU-1029782.