Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1046715#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B606341.
- aggregation creator B606342.
- aggregation creator B606343.
- aggregation creator B606344.
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- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 1046715.bibtex.
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- aggregation isPartOf urn:issn:1616-301X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Flexible nanosomes (SECosomes) enable efficient siRNA delivery in cultured primary skin cells and in the viable epidermis of ex vivo human skin".
- aggregation abstract "The extent to which nanoscale-engineered systems cross intact human skin and can exert pharmacological effects in viable epidermis is controversial. This research seeks to develop a new lipid-based nanosome that enables the effective delivery of siRNA into human skin. The major finding is that an ultrafl exible siRNA-containing nanosome—prepared using DOTAP, cholesterol, sodium cholate, and 30% ethanol penetrates into the epidermis of freshly excised intact human skin and is able to enter into the keratinocytes. The nanosomes, called surfactant-ethanolcholesterolosomes (SECosomes), show excellent size, surface charge, morphology, deformability, transfection effi ciency, stability, and skin penetration capacity after complexation with siRNA. Importantly, these nanosomes have ideal characteristics for siRNA encapsulation, in that the siRNA is stable for at least 4 weeks, they enable highly efficient transfection of in vitro cultured cells, and are shown to transport siRNA delivery through intact human skin where changes in the keratinocyte cell state are demonstrated. It is concluded that increasing flexibility in nanosomes greatly enhances their ability to cross the intact human epidermal membrane and to unload their payload into targeted epidermal cells.".
- aggregation authorList BK963134.
- aggregation endPage "4090".
- aggregation issue "23".
- aggregation startPage "4077".
- aggregation volume "20".
- aggregation aggregates 1046725.
- aggregation aggregates 1854601.
- aggregation isDescribedBy 1046715.
- aggregation similarTo adfm.201000484.
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