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- aggregation classification "A1".
- aggregation creator B332090.
- aggregation creator B332091.
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- aggregation date "2010".
- aggregation format "application/pdf".
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- aggregation isPartOf urn:issn:1613-4125.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Disposition of hop prenylflavonoids in human breast tissue".
- aggregation abstract "Hop-derived products may contain xanthohumol (XN), isoxanthohumol (IX), and the potent phytoestrogen 8-prenylnaringenin (8-PN). To evaluate the potential health effects of these prenylflavonoids on breast tissue, their concentration, nature of metabolites, and biodistribution were assessed and compared with 17 beta-estradiol (E(2)) exposure. In this dietary intervention study, women were randomly allocated to hop (n = 11; 2.04 mg XN, 1.20 mg IX, and 0.1 mg 8-PN per supplement) or control (n = 10). After a run-in of >= 4 days, three supplements were taken daily for 5 days preceding an aesthetic breast reduction. Blood and breast biopsies were analyzed using HPLC-ESI-MS/MS. Upon hop administration, XN and IX concentrations ranged between 0.72 and 17.65 nmol/L and 3.30 and 31.50 nmol/L, and between 0.26 and 5.14 pmol/g and 1.16 and 83.67 pmol/g in hydrolyzed serum and breast tissue, respectively. 8-PN however, was only detected in samples of moderate and strong 8-PN producers (0.43-7.06 nmol/L and 0.78-4.83 pmol/g). Phase I metabolism appeared to be minor (similar to 10%), whereas extensive glucuronidation was observed (> 90%). Total prenylflavonoids showed a breast adipose/glandular tissue distribution of 38/62 and their derived E(2)-equivalents were negligible compared with E(2) in adipose (384.6 +/- 118.8 fmol/g, p = 0.009) and glandular (241.6 +/- 93.1 fmol/g, p<0.001) tissue, respectively. Consequently, low doses of prenylflavonoids are unlikely to elicit estrogenic responses in breast tissue.".
- aggregation authorList BK626597.
- aggregation endPage "S294".
- aggregation issue "Suppl. 2".
- aggregation startPage "S284".
- aggregation volume "54".
- aggregation aggregates 1089277.
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