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- aggregation classification "A1".
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- aggregation creator person.
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- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1090388.bibtex.
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- aggregation isPartOf urn:issn:1362-3095.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Lack of a correlation between γH2AX foci kinetics in lymphocytes and the severity of acute normal tissue reactions during IMRT treatment for head and neck cancer".
- aggregation abstract "Purpose: To investigate the phosphorylated histone H2A isoform X (γH2AX) foci kinetics as an indicator for the development of acute normal tissue complications during Intensity-Modulated Radiotherapy (IMRT) for head and neck cancer (HNC) patients. Materials and methods: Microscopic scoring of the gH2AX foci was used to evaluate the DNA-double-strand-break repair capacity in from Ataxia-Telangiectasia (A-T) patients derived lymphoblastoid cell lines (LCL) and T-lymphocytes isolated from 31 IMRT treated HNC patients. Cells were irradiated in vitro with 0.5 Gy given at high-dose-rate (HDR) and examined at several times up to 24 h after irradiation. The patients were subdivided in three groups showing mild, moderate and severe acute normal tissue complications based on their Common Toxicity Criteria grades for dysphagia, mucositis and dermatitis during the radiotherapy course. Results: For the ATM (Ataxia-Telangiectasia-Mutated) defective LCL, a lower number of radiation-induced foci and a somewhat less efficient repair capacity was observed. No correlation was found between the gH2AX foci kinetics pattern and the risk for acute normal tissue complications among the three patient subgroups. Conclusions: Scoring of gH2AX foci after in vitro irradiation of isolated T-lymphocytes of HNC patients cannot be applied to predict for the development of acute normal tissue complications.".
- aggregation authorList BK694476.
- aggregation endPage "56".
- aggregation issue "1".
- aggregation startPage "46".
- aggregation volume "87".
- aggregation aggregates 1090395.
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- aggregation similarTo 09553002.2010.518213.
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