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- aggregation classification "A1".
- aggregation creator B89589.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "1999".
- aggregation format "application/pdf".
- aggregation hasFormat 112255.bibtex.
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- aggregation hasFormat 112255.yaml.
- aggregation isPartOf urn:issn:0946-672X.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "74As-arsenate metabolism in Flemish Giant rabbits with renal insufficiency".
- aggregation abstract "The metabolic management of carrier-free As-74-arsenate (As(V)) by uremic rabbits of the strain Flemish Giant was studied. Renal insufficiency was induced by nephrectomy of respectively 1 kidney (3/6 nephrectomy) and 1 kidney + 2/3 remaining kidney (5/6 nephrectomy). Marginal renal insufficiency developed in the 3/6 nephrectomized group, while animals of the 5/6 group became severely uremic. Renal excretion of As-74 was reduced by 90% in 5/6 nephrectomized animals 4 h after intraperitoneal injection (i.p) of the animals. The associated uremic syndrome caused a strong decrease in methylation capacity of inorganic arsenic (As-i). The second methylation step from monomethylarsonic acid (MMA) to dimethylarsinic acid (DMA) was more strongly affected than the first one, from arsenite (As(III)) to MMA. The increased availability of As-i led to more extensive binding to insoluble tissue constituents after 5/6 nephrectomy. The decreased renal reduction of As(V) led to a decrease in As(III) and an increase of As(V) and the associated As(V)-transferrin binding in plasma. Uptake of As-74-transferrin by the bone marrow might contribute to uremic anemia.".
- aggregation authorList BK231217.
- aggregation endPage "14".
- aggregation issue "1-2".
- aggregation startPage "7".
- aggregation volume "13".
- aggregation aggregates 2118146.
- aggregation isDescribedBy 112255.
- aggregation similarTo S0946-672X(99)80017-0.
- aggregation similarTo LU-112255.