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- aggregation classification "C3".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 1153225.bibtex.
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- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Comparative analysis of replication characteristics of different BoHV-1 subtypes in bovine respiratory and genital mucosa explants".
- aggregation abstract "Bovine herpes virus 1 (BoHV-1) belongs to the subfamily of the Alphaherpesvirinae. In general, alphaherpesviruses use the epithelium of the upper respiratory and/or genital tract as a preferential site for primary replication. BoHV-1 may replicate at both sites and causes two major clinical entities designated infectious bovine rhinotracheïtis (IBR) and infectious pustular vulvovaginitis/balanoposthitis (IPV/IPB) in cattle. It has been hypothesized that subtype 1.1 invades preferentially the upper respiratory mucosa where subtype 1.2 favors replication at the peripheral genital tract. However, some in vivo data are in contrast with that hypothesis. A thorough study of primary replication at both mucosae could elucidate this question. In the present study, we established a bovine respiratory and genital organ culture. Bovine respiratory and genital mucosal explants of the same animal were inoculated with several BoHV-1 subtypes. A quantitative analysis of viral mucosal invasion was performed at 0, 24, 48 and 72 hours post inoculation (pi) by measuring plaque latitude and penetration depth underneath the basement membrane (BM). BoHV-1 spreads plaquewise in the epithelium and penetrates the BM. Viral plaques could be observed at 24hpi for all isolates in both respiratory and genital mucosa explants with the plaque latitude increasing over time. At 24hpi, all the different subtypes spread more efficiently lateral in the epithelium of the genital tract compared to the respiratory tract. On the contrary, all BoHV-1 subtypes exhibit a more profound invasion capacity in the respiratory tract at 24h pi compared to the genital tract. These findings take the edge of the belief of the existence of specific mucosa tropisms off different BoHV-1 subtypes.".
- aggregation authorList BK310542.
- aggregation aggregates 2051093.
- aggregation isDescribedBy 1153225.
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