Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1154230#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B459783.
- aggregation creator B459784.
- aggregation creator B459785.
- aggregation creator B459786.
- aggregation creator B459787.
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- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1154230.bibtex.
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- aggregation isPartOf urn:issn:0066-4804.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Veterinary Sciences".
- aggregation title "Sensitive in vitro system to assess morphological and biochemical effects of praziquantel and albendazole on Taenia solium cysts".
- aggregation abstract "Neurocysticercosis resulting from Taenia solium infections is a major cause of adult-acquired seizures worldwide. Disease is caused by larval cysts, and treatment consists of the anthelmintic drugs albendazole or praziquantel. There are no standard methods to assess drug activity to T. solium cysts in vitro. Morphological, functional, and biochemical changes that might reflect damaging (inhibiting, cytotoxic) drug effects were analyzed after exposure of cysts to albendazole sulfoxide (ABZ-SO), the major active metabolite of the drug in vivo, praziquantel (PZQ), or combinations of both. PZQ exposure led to a decrease in cyst size and inhibition of evagination, whereas ABZ-SO exposure resulted in minimal changes. Alkaline phosphatase (AP) is normally secreted by cysts, and both drugs inhibited AP secretion at concentrations of 5 and 50 ng/ml for PZQ and ABZ-SO, respectively. Some combinations of both drugs resulted in additive and/or synergistic activities. Parasite-specific antigen, detected in the cerebrospinal fluid and blood of infected patients, is also normally secreted by T. solium cysts. Antigen secretion was similarly inhibited by ABZ-SO and PZQ and a combination of both drugs, suggesting that inhibition of secretion is a common downstream consequence of the activities of both drugs. These studies establish quantitative methods to measure in vitro anthelmintic activity and suggest combination therapy with ABZ-SO and PZQ may have clinical benefit.".
- aggregation authorList BK797300.
- aggregation endPage "217".
- aggregation issue "1".
- aggregation startPage "211".
- aggregation volume "55".
- aggregation aggregates 1154321.
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- aggregation similarTo AAC.00761-10.
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