Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1181428#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B444460.
- aggregation creator B444461.
- aggregation creator B444462.
- aggregation creator B444463.
- aggregation creator B444464.
- aggregation creator B444465.
- aggregation creator B444466.
- aggregation creator person.
- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 1181428.bibtex.
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- aggregation hasFormat 1181428.dc.
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- aggregation isPartOf urn:issn:1567-2026.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Haptoglobin phenotype correlates with the extent of cerebral deep white matter lesions in hypertensive patients".
- aggregation abstract "Cerebral white matter lesions (WMLs), due to small vessel disease, can be regarded as an early "silent" sign of hypertensive cerebral end-organ damage. As haptoglobin (Hp) phenotype has earlier been associated with symptomatic vascular disease, we now examined the relationship between Hp phenotype and asymptomatic cerebral small vessel disease, manifested by deep and periventricular WMLs, in hypertensive patients. We determined Hp phenotype using starch gel electrophoresis in 152 hypertensive patients without symptomatic vascular disease. We found 26 (17.1%) Hp1-1, 89 (58.6%) Hp2-1 and 37 (24.3%) Hp2-2. Volumes of deep and periventricular WMLs were quantitatively measured on brain MR images. Patients were ranked in 5 categories according to ascending WMLs volumes. Compared to Hp2-2, Hp1-1 was associated with larger deep WMLs volumes when adjusted for age, gender, brain volume, 24-hour mean arterial pressure, duration of hypertension and previous antihypertensive treatment (ordinal regression analysis, OR 2.77, 95%CI 1.08-7.11, p=0.034). No association was found between Hp phenotype and periventricular WMLs. Hp1-1 phenotype correlates with the extent of hypertensive deep white matter damage. One of the possibilities is that this is related to lower regenerating power against endothelial injury in Hp1-1 individuals.".
- aggregation authorList BK775806.
- aggregation endPage "5".
- aggregation issue "1".
- aggregation startPage "1".
- aggregation volume "7".
- aggregation aggregates 1204806.
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