Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1181972#aggregation> ?p ?o. }
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- aggregation classification "C3".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
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- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1181972.bibtex.
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- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Science General".
- aggregation title "Protection of pigs against genital Chlamydia trachomatis challenge by parenteral or mucosal DNA immunization".
- aggregation abstract "We have evaluated protection against a genital Chlamydia trachomatis infection in a pig challenge model. Protection was promoted by the porcine granulocyte macrophage-colony stimulating factor (GM-CSF), the Escherichia coli thermo-labile enterotoxin LT as an exceptionally potent mucosa-binding molecule and by a major outer membrane protein (MOMP)-based DNA vaccine carrying CpG motifs incorporated in the plasmid backbone. Protection achieved by mucosal (vaginal and nasal) immunization will be compared to systemic (intradermal) immunization. We could demonstrate that mucosal administration leads to significant protection against genital C. trachomatis challenge as significantly less severe macroscopic lesions, less chlamydial shedding and replication in the urogenital tract was demonstrated in the vaccinated animals. Also, significantly higher proliferative responses of peripheral blood lymphocytes were observed. Furthermore, the combination of nasal and vaginal immunization could induce serum antibody titers upon immunization and early upon challenge with C. trachomatis serovar E. However, the infection could not be eradicated. Systemic immunization was significantly less efficient at eliciting protection, which emphasizes the need for a mucosal vaccine in order to obtain significant protection against genital C. trachomatis infection.".
- aggregation authorList BK84294.
- aggregation aggregates 1216028.
- aggregation isDescribedBy 1181972.
- aggregation similarTo LU-1181972.