Matches in UGent Biblio for { <https://biblio.ugent.be/publication/118703#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B124210.
- aggregation creator B124211.
- aggregation creator person.
- aggregation creator person.
- aggregation date "1999".
- aggregation hasFormat 118703.bibtex.
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- aggregation isPartOf urn:issn:0002-9645.
- aggregation language "eng".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Evaluation of the role of endotoxin and cortisol on modulation of CD18 adhesion receptors in cows with mastitis caused by Escherichia coli.".
- aggregation abstract "Objective-To determine the effect of mastitis caused by Escherichia coil on expression of CD18 cell surface receptors and to evaluate the involvement. and regulation of receptors by lipopolysaccharide (LPS) and cortisol. Animals-11 clinically normal lactating Holstein-Friesian cows. Procedure-Binding of CD18 monoclonal antibodies to neutrophils was studied, using flow cytometry, before and after intramammary inoculation of E coil organisms. Effect of LPS and cortisol on expression of adhesion receptors was investigated, using a whole-blood model. Results-Expression of CD18 adhesion receptors on bovine neutrophils increased 35% by 12 hours after intramammary inoculation of E coli By 24 hours after inoculation, the number of receptors had returned to control values. High cortisol concentrations (100 nmol/L) were seen 12 to 18 hours after inoculation. Addition of LPS to blood induced a 30% increase in the number of CD18 receptors, and maximal number of receptors was expressed at an LPS concentration of 0.1 ng/ml, A decrease in the number of CD18 receptors was induced by incubation with cortisol or dexamethasone before challenge-exposure with LPS. Conclusions-An increase in the number of CD18 receptors on neutrophils is mediated by local production of LPS, Subsequent endogenous release of cortisol may prevent additional increases in the number of receptors. Clinical Relevance-During acute mastitis caused by E coli, there is an increase in the number of CD18 receptors on circulating neutrophils. Cortisol induces a decrease in the number of CD18 receptors, probably modulating the acute inflammatory response in mammary glands of lactating cows.".
- aggregation authorList BK319176.
- aggregation endPage "540".
- aggregation issue "5".
- aggregation startPage "534".
- aggregation volume "60".
- aggregation isDescribedBy 118703.
- aggregation similarTo LU-118703.