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- aggregation classification "C1".
- aggregation creator B49805.
- aggregation creator B49806.
- aggregation creator person.
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- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1196747.bibtex.
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- aggregation isPartOf urn:isbn:9780956291417.
- aggregation language "eng".
- aggregation publisher "All American Printing".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Numerical model for CFD-simulation of the flow field in the anastomosis region of coronary bypasses".
- aggregation abstract "Coronary artery bypass surgery is a treatment for ischemic heart disease and can increase life quality and expectancy. The results after the treatment depend largely on the patency of the bypass grafts, which are used to bypass the narrowed arteries on the heart. Long-term patency is mainly determined by the progression of atherosclerosis and intimal hyperplasia (IH) within the bypass grafts, which are believed to be related to unfavourable wall shear stress (e.g. low and oscillatory WSS) exerted on the endothelial cells. To investigate the potential role of hemodynamic forces on the endothelial cells and the impact of the severity of the bypassed arterial stenosis on the flow fields, we developed a computational model of a LIMA-to-LAD anastomosis region obtained from a porcine in-vivo cast. In addition, the same porcine experiment provided the necessary up- and downstream boundary conditions for the simulations. The model has been applied to simulate the flow field in 5 cases, corresponding with 100, 97, 90, 75 and 0% LAD stenosis, in order to quantify the effect of the stenosis on resulting flow fields and on WSS distributions. Low stenosis degrees are associated with competitive LAD and LIMA flow and low WSS in the LIMA, which might contribute to WSS-related remodeling and suboptimal performance of the LIMA bypass.".
- aggregation authorList BK126497.
- aggregation endPage "390".
- aggregation startPage "387".
- aggregation aggregates 1196770.
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