Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1206204#aggregation> ?p ?o. }
Showing items 1 to 50 of
50
with 100 items per page.
- aggregation classification "A1".
- aggregation creator B217577.
- aggregation creator B217578.
- aggregation creator B217579.
- aggregation creator B217580.
- aggregation creator B217581.
- aggregation creator B217582.
- aggregation creator B217583.
- aggregation creator B217584.
- aggregation creator B217585.
- aggregation creator B217586.
- aggregation creator B217587.
- aggregation creator B217588.
- aggregation creator B217589.
- aggregation creator B217590.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1206204.bibtex.
- aggregation hasFormat 1206204.csv.
- aggregation hasFormat 1206204.dc.
- aggregation hasFormat 1206204.didl.
- aggregation hasFormat 1206204.doc.
- aggregation hasFormat 1206204.json.
- aggregation hasFormat 1206204.mets.
- aggregation hasFormat 1206204.mods.
- aggregation hasFormat 1206204.rdf.
- aggregation hasFormat 1206204.ris.
- aggregation hasFormat 1206204.txt.
- aggregation hasFormat 1206204.xls.
- aggregation hasFormat 1206204.yaml.
- aggregation isPartOf urn:issn:0305-7453.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Comparison of phenotypic and genotypic tropism determination in triple-class-experienced HIV patients eligible for maraviroc treatment".
- aggregation abstract "Determination of HIV-1 tropism is a pre-requisite to the use of CCR5 antagonists. This study evaluated the potential of population genotypic tropism tests (GTTs) in clinical practice, and the correlation with phenotypic tropism tests (PTTs) in patients accessing routine HIV care. Forty-nine consecutive plasma samples for which an original Trofile(TM) assay was performed were obtained from triple-class-experienced patients in need of a therapy change. Viral tropism was defined as the consensus of three or more tropism calls obtained from the combination of two independent population PTT assays (Trofile Biosciences, San Francisco, CA, USA, and Virco, Beerse, Belgium), population GTTs and GTTs based on ultra-deep sequencing. If no consensus was reached, a clonal PTT was performed in order to finalize the tropism call. This two-step approach allowed the definition of a reference tropism call. According to the reference tropism result, 35/49 samples were CCR5 tropic (R5) (patients eligible for maraviroc treatment) and 14/49 were assigned as non-R5 tropic. The non-R5 samples [patients not eligible for maraviroc treatment according to the FDA/European Medicines Agency (EMEA) label] group included both the CXCR4 (X4) samples and the dual and mixed CCR5/CXCR4 (R5/X4) samples. Compared with Trofile(TM) population PTTs, population GTTs showed a higher sensitivity (97%) and a higher negative predictive value (91%), but almost equal specificity and an equal positive predictive value. In line with recent reports from clinical trial data, our data support the use of population genotypic tropism testing as a tool for tropism determination before the start of maraviroc.".
- aggregation authorList BK480261.
- aggregation endPage "272".
- aggregation issue "2".
- aggregation startPage "265".
- aggregation volume "66".
- aggregation aggregates 1207738.
- aggregation isDescribedBy 1206204.
- aggregation similarTo dkq458.
- aggregation similarTo LU-1206204.