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- aggregation classification "A1".
- aggregation creator B175401.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1229546.bibtex.
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- aggregation isPartOf urn:issn:1080-0549.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Viruses and cytotoxic T lymphocytes in type 1 diabetes".
- aggregation abstract "Histopathological studies on pancreas tissues from individuals with recent-onset type 1 diabetes (T1D) consistently find that CD8 T cells substantially contribute to the formation of islet lesions. CD8 T cells reactive against islet-associated antigens can also be found in blood samples from T1D patients. Mechanistic studies on the pathogenic role of this T cell subset have mostly focused on two animal models, i.e., the non-obese diabetic mouse and the virally induced rat insulin promoter-lymphocytic choriomeningitis virus model. Data were obtained in support of a role for viral infection in expanding a population of diabetogenic cytotoxic T lymphocytes. In view of the theorized association of viral infection with initiation of islet autoimmunity and progression to clinically overt disease, CD8 T cells thus represent an attractive target for immunotherapy. We will review here arguments in favor of a pivotal role for CD8 T cells in driving T1D development and speculate on etiologic agents that may provoke their aberrant activation.".
- aggregation authorList BK429438.
- aggregation endPage "178".
- aggregation issue "2".
- aggregation startPage "169".
- aggregation volume "41".
- aggregation aggregates 1229725.
- aggregation isDescribedBy 1229546.
- aggregation similarTo s12016-010-8220-4.
- aggregation similarTo LU-1229546.