Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1231110#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B582618.
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- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1231110.bibtex.
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- aggregation isPartOf urn:issn:0022-2623.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase".
- aggregation abstract "Infections caused by hepatitis C virus (HCV) are a significant world health problem for which novel therapies are in urgent demand The polymerase of HCV is responsible for the replication of viral genome and has been a prime target for drug discovery efforts Here, we report on the further development of tetracyclic indole inhibitors, binding to an allosteric site on the thumb domain Structure activity relationship (SAR) studies around an indolo-benzoxazocine scaffold led to the identification of compound 33 (MK-3281), an inhibitor with good potency in the HCV subgenomic replication assay and attractive molecular properties suitable for a clinical candidate The compound caused a consistent decrease in viremia in vivo using the chimeric mouse model of HCV infection.".
- aggregation authorList BK934632.
- aggregation endPage "301".
- aggregation issue "1".
- aggregation startPage "289".
- aggregation volume "54".
- aggregation aggregates 1237443.
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