Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1231206#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B286791.
- aggregation creator B286792.
- aggregation creator B286793.
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- aggregation creator person.
- aggregation creator person.
- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 1231206.bibtex.
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- aggregation isPartOf urn:issn:0022-1007.
- aggregation language "eng".
- aggregation rights "I have retained and own the full copyright for this publication".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation".
- aggregation abstract "End-stage liver disease caused by chronic hepatitis C virus (HCV) infection is a leading cause for liver transplantation (LT). Due to viral evasion from host immune responses and the absence of preventive antiviral strategies, reinfection of the graft is universal. The mechanisms by which the virus evades host immunity to reinfect the liver graft are unknown. In a longitudinal analysis of six HCV-infected patients undergoing LT, we demonstrate that HCV variants reinfecting the liver graft were characterized by efficient entry and poor neutralization by antibodies present in pretransplant serum compared with variants not detected after transplantation. Monoclonal antibodies directed against HCV envelope glycoproteins or a cellular entry factor efficiently cross-neutralized infection of human hepatocytes by patient-derived viral isolates that were resistant to autologous host-neutralizing responses. These findings provide significant insights into the molecular mechanisms of viral evasion during HCV reinfection and suggest that viral entry is a viable target for prevention of HCV reinfection of the liver graft.".
- aggregation authorList BK569443.
- aggregation endPage "2031".
- aggregation issue "9".
- aggregation startPage "2019".
- aggregation volume "207".
- aggregation aggregates 1232680.
- aggregation isDescribedBy 1231206.
- aggregation similarTo jem.20090766.
- aggregation similarTo LU-1231206.