Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1234131#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B435817.
- aggregation creator B435818.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2009".
- aggregation format "application/pdf".
- aggregation hasFormat 1234131.bibtex.
- aggregation hasFormat 1234131.csv.
- aggregation hasFormat 1234131.dc.
- aggregation hasFormat 1234131.didl.
- aggregation hasFormat 1234131.doc.
- aggregation hasFormat 1234131.json.
- aggregation hasFormat 1234131.mets.
- aggregation hasFormat 1234131.mods.
- aggregation hasFormat 1234131.rdf.
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- aggregation hasFormat 1234131.txt.
- aggregation hasFormat 1234131.xls.
- aggregation hasFormat 1234131.yaml.
- aggregation isPartOf urn:issn:0022-2623.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain".
- aggregation abstract "Fatty acid amide hydrolyase (FAAH) is one of the main enzymes responsible for terminating the signaling of endocannabinoids in the brain. Imaging FAAH in vivo using PET or SPECT is important to deeper understanding of its role in neuropsychiatric disorders. However, at present, no radioligand is available for mapping the enzyme in vivo. Here, we synthesized 18 aryl analogues of anandamide, FAAH's endogenous substrate, and in vitro evaluated their potential as metabolic trapping tracers. Interaction studies with recombinant FAAH revealed good to very good interaction of the methoxy substituted aryl anandamide analogues 17, 18, 19, and 20 with FAAH and they were identified as competing substrates, Compounds 17 and 18 did not display significant binding to CB1 and CB2 cannabinoid receptors and stand out as potential candidate metabolic trapping tracers. They were successfully labeled with C-11 in good yields and high radiochemical purity and displayed brain uptake in C57BL/6J mice. Radioligands [C-11]-17 and [C-11]-18 merit further investigation in vivo.".
- aggregation authorList BK759608.
- aggregation endPage "4622".
- aggregation issue "15".
- aggregation startPage "4613".
- aggregation volume "52".
- aggregation aggregates 1235903.
- aggregation isDescribedBy 1234131.
- aggregation similarTo jm900324e.
- aggregation similarTo LU-1234131.