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- aggregation classification "A1".
- aggregation creator person.
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- aggregation date "2010".
- aggregation format "application/pdf".
- aggregation hasFormat 1234682.bibtex.
- aggregation hasFormat 1234682.csv.
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- aggregation isPartOf urn:issn:1619-7070.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Reduced dimethylaminoethanol in [18F]fluoromethylcholine: an important step towards enhanced tumour visualization".
- aggregation abstract "[F-18]Fluoromethylcholine ([F-18]FCho) is a radiotracer generally used for tumour visualization in patients. Due to high levels of dimethylaminoethanol (DMAE) remaining in [F-18]FCho solutions synthesized by currently available methods, tumour visualization might be compromised. An improved purification method involving an optimized purification step for reducing the levels of DMAE was conceived. The physiological explanation for the interference of residual DMAE in [F-18]FCho pharmacokinetics was further elaborated in a xenograft mouse model. The use of a series of polymer solid-phase extraction cartridges (Oasis HLB/WCX), instead of the commonly used combination of tC18 and Accell CM cartridges, reduced DMAE levels from 402.2 +/- 49.6 ppm to 3.0 +/- 0.5 ppm. Subsequent in vitro tests proved that (1) [F-18]FCho uptake was reduced in the presence of DMAE at concentrations above 0.5 A mu M and (2) DMAE is a competitive inhibitor of [F-18]FCho transport. In vivo experiments in xenograft mouse models corroborated reduced tumour uptake at DMAE plasma levels of about 2.5 A mu M as found in patients injected with contaminated [F-18]FCho. Residual DMAE, even at levels below choline plasma concentrations found during fasting, compromises [F-18]FCho uptake in vivo and care should be taken to avoid its interference in molecular imaging with [F-18]FCho.".
- aggregation authorList BK937098.
- aggregation endPage "2145".
- aggregation issue "11".
- aggregation startPage "2136".
- aggregation volume "37".
- aggregation aggregates 1234694.
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- aggregation similarTo s00259-010-1508-z.
- aggregation similarTo LU-1234682.