Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1234759#aggregation> ?p ?o. }
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- aggregation classification "A1".
- aggregation creator B175098.
- aggregation creator B175099.
- aggregation creator B175100.
- aggregation creator B175101.
- aggregation creator B175102.
- aggregation creator B175103.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2011".
- aggregation format "application/pdf".
- aggregation hasFormat 1234759.bibtex.
- aggregation hasFormat 1234759.csv.
- aggregation hasFormat 1234759.dc.
- aggregation hasFormat 1234759.didl.
- aggregation hasFormat 1234759.doc.
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- aggregation hasFormat 1234759.txt.
- aggregation hasFormat 1234759.xls.
- aggregation hasFormat 1234759.yaml.
- aggregation isPartOf urn:issn:1074-7613.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "An unexpected role for uric Acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma".
- aggregation abstract "Although deposition of uric acid (UA) crystals is known as the cause of gout, it is unclear whether UA plays a role in other inflammatory diseases. We here have shown that UA is released in the airways of allergen-challenged asthmatic patients and mice, where it was necessary for mounting T helper 2 (Th2) cell immunity, airway eosinophilia, and bronchial hyperreactivity to inhaled harmless proteins and clinically relevant house dust mite allergen. Conversely, administration of UA crystals together with protein antigen was sufficient to promote Th2 cell immunity and features of asthma. The adjuvant effects of UA did not require the inflammasome (Nlrp3, Pycard) or the interleukin-1 (Myd88, IL-1r) axis. UA crystals promoted Th2 cell immunity by activating dendritic cells through spleen tyrosine kinase and PI3-kinase δ signaling. These findings provide further molecular insight into Th2 cell development and identify UA as an essential initiator and amplifier of allergic inflammation.".
- aggregation authorList BK429012.
- aggregation endPage "540".
- aggregation issue "4".
- aggregation startPage "527".
- aggregation volume "34".
- aggregation aggregates 3146651.
- aggregation aggregates 3146652.
- aggregation isDescribedBy 1234759.
- aggregation similarTo j.immuni.2011.03.015.
- aggregation similarTo LU-1234759.