Matches in UGent Biblio for { <https://biblio.ugent.be/publication/1245111#aggregation> ?p ?o. }
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- aggregation classification "C3".
- aggregation creator B125691.
- aggregation creator B125692.
- aggregation creator B125693.
- aggregation creator B125694.
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- aggregation date "2011".
- aggregation hasFormat 1245111.bibtex.
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- aggregation hasFormat 1245111.doc.
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- aggregation language "eng".
- aggregation subject "Veterinary Sciences".
- aggregation title "Stress induced Salmonella Typhimurium re-excretion by pigs is associated with cortisol induced increased intracellular proliferation in porcine macrophages".
- aggregation abstract "Infections of pigs with Salmonella enterica subspecies enterica serovar Typhimurium (Salmonella Typhimurium) often result in the development of carriers that intermittently excrete Salmonella in very low numbers. During periods of stress, such as transport to the slaughter house, recrudescence of Salmonella may occur. The mechanism of stress related re-excretion of Salmonella by pigs is poorly understood. Therefore, the aim of the presented study was to determine the role of the stress hormone cortisol on Salmonella re-excretion by pigs. First, an in vivo infection model was optimized to reproduce stress induced re-excretion of Salmonella Typhimurium by pigs. We showed that a 24 hour feed withdrawal increases the Salmonella Typhimurium load in pigs, which is correlated with increased cortisol blood levels. A second in vivo trial, showed that the stress related re-excretion of Salmonella Typhimurium in pigs can be induced by intramuscular injection of dexamethasone, a synthetic member of the glucocorticoids, at a concentration (2 mg/kg) that does not cause immunosuppression of the pig (Flaming et al., 1994). Furthermore we demonstrated that cortisol promotes intracellular proliferation of Salmonella Typhimurium in porcine alveolar macrophages, but not in intestinal epithelial cells (IPEC-J2), at a concentration (1 µM) that did not exert a notable effect on porcine cell viability. Whether this increased intracellular proliferation is triggered by cortisol-induced changes in the host cell or by direct interaction of the bacterium with cortisol, was investigated via microarray analysis. This pointed out that cortisol (1 µM) does not cause any significant changes in the gene expression of Salmonella Typhimurium, which implies that the enhanced survival of the bacteria is probably caused by an indirect effect through the cell. These results highlight the role of cortisol in the re-excretion of Salmonella Typhimurium by pigs and they provide new evidence for the role of microbial endocrinology in host-pathogen interactions. Reference: Flaming, K.P., Gogg, B.L., Roth, F., Roth, J.A. 1994. Pigs are relatively resistant to dexamethasone induced immunosuppression 4, 218-225.".
- aggregation authorList BK322550.
- aggregation isDescribedBy 1245111.
- aggregation similarTo LU-1245111.