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- aggregation classification "A1".
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2001".
- aggregation format "application/pdf".
- aggregation hasFormat 141877.bibtex.
- aggregation hasFormat 141877.csv.
- aggregation hasFormat 141877.dc.
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- aggregation hasFormat 141877.doc.
- aggregation hasFormat 141877.json.
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- aggregation hasFormat 141877.yaml.
- aggregation isPartOf urn:issn:0022-1007.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "A mediator role for metallothionein in tumor necrosis factor-induced lethal shock".
- aggregation abstract "Tumor necrosis factor (TNF) is a proinflammatory cytokine, which is centrally involved in several inflammatory disorders. Administration of TNF leads to a potentially lethal systemic inflammatory response syndrome (SIRS). We observed that (a) mice lacking functional genes for metallothionein 1 and 2 (MT-null) were protected compared with wild-type controls (P = 0.0078), and (b) mice overexpressing MT-1 (MT-TG) were more sensitized for the lethal effect of TNF than control ni-ice (P = 0.0003), indicating a mediating role for MT in TNF induced SIRS. As NIT is involved in the body zinc homeostasis, we tested whether zinc-deprivation or -supplementation alters the response to TNF. Although zinc-depletion strongly sensitized (P = 0.036), and pretreatment with zinc sulfate (ZnSO4) conferred protection against the deleterious effects of TNF (P < 0.0002), it was also found that the protection provided by zinc is independent of MT. Our observation that hsp70 is strongly induced in jejunum after ZnSO4 treatment, suggests a contribution of hsp70 in the protection against TNF. In addition, ZnSO4 cotreatment allowed complete regression of inoculated tumors with TNF and interferon gamma, leading to a significantly better survival (P = 0.0045).".
- aggregation authorList BK137426.
- aggregation endPage "1624".
- aggregation issue "11".
- aggregation startPage "1617".
- aggregation volume "194".
- aggregation aggregates 2933415.
- aggregation isDescribedBy 141877.
- aggregation similarTo jem.194.11.1617.
- aggregation similarTo LU-141877.