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- aggregation classification "A1".
- aggregation creator B137447.
- aggregation creator B137448.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "1992".
- aggregation hasFormat 151216.bibtex.
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- aggregation hasFormat 151216.doc.
- aggregation hasFormat 151216.json.
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- aggregation isPartOf urn:issn:0171-9335.
- aggregation language "eng".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Interleukin-1 is a motility factor for human breast carcinoma cells in vitro: additive effect with interleukin-6".
- aggregation abstract "Interleukin-1beta (Il-1beta) and interleukin-1alpha (Il-1alpha) were shown to act as motility factors for the human breast carcinoma cell lines SK-BR-3 and ZR-75-1 in vitro. Both cytokines induced transition from the stationary to the motile phenotype (spreading). Il-1beta stimulated translocation, shape change and random migration (chemokinesis) of SK-BR-3 cells as demonstrated by time-lapse video recordings and by a modified Boyden chamber assay. Interleukin-6 (Il-6) stimulated spreading of the SK-BR-3 cells; an additive effect with Il-1beta on spreading and fast plasma membrane movements was evidenced. In the SK-BR-3 cell line, the signal transduction of Il-1beta and Il-6 differed, since only the effect of Il-6 on spreading was sensitive to pertussis toxin. Both Il-1beta and Il-6 required protein synthesis to stimulate spreading, since cycloheximide inhibited the effect of the cytokines. Induction of an autocrine loop of Il-6 in the SK-BR-3 cells by Il-1beta was unlikely, since after stimulation with Il-1beta, no induction of Il-6 activity was measured, nor was inhibition of stimulated spreading seen in the presence of an antiserum against Il-6. Addition of Il-8 or of an antiserum against Il-8 did not affect spreading. We concluded that Il-1 and Il-6 could act as motility factors for human breast carcinoma cells, in both an independent and an additive way. Human squamous cell carcinoma COLO-16 cells were found to secrete factors with similar effects on the SK-BR-3 and ZR-75-1 cells as the aforementioned cytokines. Although the presence of Il-1alpha and Il-6 activity in the COLO-16 conditioned medium was confirmed, a number of arguments were found to assume that still other factors beside these two cytokines were responsible for the motility-stimulating effect of the COLO-16 conditioned medium.".
- aggregation authorList BK351345.
- aggregation endPage "457".
- aggregation issue "2".
- aggregation startPage "449".
- aggregation volume "59".
- aggregation isDescribedBy 151216.
- aggregation similarTo LU-151216.