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- aggregation classification "A1".
- aggregation creator B39845.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation creator person.
- aggregation date "2002".
- aggregation format "application/pdf".
- aggregation hasFormat 154635.bibtex.
- aggregation hasFormat 154635.csv.
- aggregation hasFormat 154635.dc.
- aggregation hasFormat 154635.didl.
- aggregation hasFormat 154635.doc.
- aggregation hasFormat 154635.json.
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- aggregation hasFormat 154635.txt.
- aggregation hasFormat 154635.xls.
- aggregation hasFormat 154635.yaml.
- aggregation isPartOf urn:issn:0027-8424.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy".
- aggregation abstract "Tumor necrosis factor (TNF) is a central mediator in lethal shock and an interesting cytokine for anticancer therapy. To inhibit TNF-induced lethal shock, it is important to identify protective genes. Here we demonstrate that the SPRET/Ei mouse strain, derived from Mus spretus, exhibits an extremely dominant resistance to TNF-induced lethal inflammation. An interspecific backcross experiment revealed that the TNF hyporesponse is linked to loci on chromosomes 2, 6, and 11. Treatment of inoculated tumors with TNF and IFN-gamma leads to regression and a highly reduced toxicity in (C57BL/6 x SPRET/Ei)F-1 mice.".
- aggregation authorList BK100870.
- aggregation endPage "9345".
- aggregation issue "14".
- aggregation startPage "9340".
- aggregation volume "99".
- aggregation aggregates 2933665.
- aggregation isDescribedBy 154635.
- aggregation similarTo pnas.142293699.
- aggregation similarTo LU-154635.