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- aggregation classification "A1".
- aggregation creator person.
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- aggregation date "2002".
- aggregation hasFormat 156258.bibtex.
- aggregation hasFormat 156258.csv.
- aggregation hasFormat 156258.dc.
- aggregation hasFormat 156258.didl.
- aggregation hasFormat 156258.doc.
- aggregation hasFormat 156258.json.
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- aggregation hasFormat 156258.txt.
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- aggregation hasFormat 156258.yaml.
- aggregation isPartOf urn:issn:1148-5493.
- aggregation language "eng".
- aggregation subject "Biology and Life Sciences".
- aggregation title "Comparison of leptin- and interleukin-6-regulated expression of the rPAP gene family: evidence for differential co-regulatory signals".
- aggregation abstract "The pancreatitis-associated protein (PAP)/regenerating protein (REG) family represents a complex group of small secretory proteins, which can function as acute phase reactants, lectins, antiapoptotic factors or growth factors for pancreatic beta-cells and neural cells. Transcriptional induction of rPAP/Reg genes was studied here in PC12 cells made responsive to leptin. Northern-blots showed quantitative differences in induction of four major family members by leptin and IL-6. Surprisingly, induction by leptin was strongly enhanced upon forskolin co-treatment whereas induction by IL-6 was counteracted. Functional studies involving progressive rPAP I promoter deletions showed, in the case of leptin, a clear correlation with predicted cis-regulatory elements. Leptin-induced stimulation was dependent on STAT3, since over-expression of dominant-negative STAT3, but not of dominant-negative STAT1, completely blocked transcriptional activation. In case of IL-6, an enhancer element outside the cloned promoter fragment is required for full stimulation. The effects of forskolin in a leptin and IL-6 context could not be explained at the promoter level, but rather events occurring upstream in the signalling cascade must be postulated to explain the differential co-regulatory effects.".
- aggregation authorList BK262422.
- aggregation endPage "85".
- aggregation issue "1".
- aggregation startPage "78".
- aggregation volume "13".
- aggregation isDescribedBy 156258.
- aggregation similarTo LU-156258.