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- aggregation classification "A1".
- aggregation creator B38317.
- aggregation creator B38318.
- aggregation creator B38319.
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- aggregation date "2000".
- aggregation format "application/pdf".
- aggregation hasFormat 171577.bibtex.
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- aggregation isPartOf urn:issn:0004-3591.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Human cartilage gp-39+, CD16+monocytes in peripheral blood and synovium: correlation with joint destruction in rheumatoid arthritis".
- aggregation abstract "Objective. To investigate the expression of human cartilage (HC) gp-39, a possible autoantigen in rheumatoid arthritis (RA), in peripheral brood and synovium, to characterize its cellular source, and to analyze correlations with clinical features, Methods. The expression of HC gp-39 in synovium and peripheral blood mononuclear cells (PBMC) was assessed by immunohistochemistry and flow cytometry, Synthesis and secretion were investigated by both reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. Results. PBRIC expressing HC gp-39 were increased in RA patients compared with spondylarthropathy patients (P = 0.0029) and with healthy control subjects (P = 0.0013), HC gp-39+ cells were also slightly overrepresented in RA synovium (P = 0.01). In both blood and synovium, HC gp-39+ cells were identified as CDT4dim, CD16+ monocytes, a phenotype which can differentiate from classic CD14++ monocytes by maturation in vitro. HC gp-39 messenger RNA was detected in RA synovium and PBMC, and PBMC secreted HC gp-39 in vitro. The number of HC gp-39+ PBMC correlated with serum levels of C-reactive protein (r = 0.39, P = 0.003) and HC gp-39 (r = 0.52, P = 0.014). HC gp-39 expression in Ri synovial lining correlated with joint destruction (r = 0.77, P < 0.001), Conclusion, CD16+ monocytes, a cellular source of HC gp-39 in vivo, are overrepresented in both RA peripheral blood and synovial tissue. The presence of HC gp-39+ cells in RA synovium is correlated with the degree of joint destruction. These data support a role of these cells in the local autoimmune response that leads to chronic inflammation and joint destruction.".
- aggregation authorList BK97118.
- aggregation endPage "1243".
- aggregation issue "6".
- aggregation startPage "1233".
- aggregation volume "43".
- aggregation aggregates 1993355.
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- aggregation similarTo 1529-0131(200006)43:61233::AID-ANR63.0.CO;2-9.
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