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- aggregation classification "A1".
- aggregation creator B42365.
- aggregation creator B42366.
- aggregation creator B42367.
- aggregation creator person.
- aggregation date "1998".
- aggregation format "application/pdf".
- aggregation hasFormat 173747.bibtex.
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- aggregation isPartOf urn:issn:0140-7783.
- aggregation language "eng".
- aggregation rights "I have transferred the copyright for this publication to the publisher".
- aggregation subject "Medicine and Health Sciences".
- aggregation title "Effect of cephapirin and mecillinam on the phagocytic and respiratory burst activity of neutrophil leukocytes isolated from bovine blood.".
- aggregation abstract "Antimicrobial therapy is the most commonly used treatment of bacterial infections in dairy cows, Polymorphonuclear neutrophil leukocytes (PMN) play an important role in the first line defence against invading bacteria and it is important that the function of PMN is not compromised by antibiotics. We investigated the in vitro effect of cephapirin, a first generation cephalosporin, and mecillinam, an amidinopenicillin with activity against mainly Gramnegative bacteria, on phagocytosis and respiratory burst activity of PMN isolated from bovine blood, After in vitro incubation of PMN with different concentrations of the antibiotics, phagocytosis was evaluated by flow cytometry and respiratory burst activity was evaluated by registration of chemiluminescence (CL) with a luminometer, None of the investigated concentrations of cephapirin and mecillinam had an effect in vitro on phagocytosis of Escherichia coli by PMN, At high concentrations (100 and 1000 mu g/mL), cephapirin and mecillinam reduced the respiratory burst activity of PMN. Part of these suppressive effects could be ascribed to oxidant scavenging, Inhibitory effects of cephapirin were stronger than mecillinam. In conclusion, cephapirin and mecillinam did not seem to affect antibacterial activity of PMN isolated from bovine blood in vitro at therapeutic concentrations.".
- aggregation authorList BK106537.
- aggregation endPage "427".
- aggregation issue "6".
- aggregation startPage "421".
- aggregation volume "21".
- aggregation aggregates 985680.
- aggregation isDescribedBy 173747.
- aggregation similarTo LU-173747.